| Literature DB >> 26560683 |
Marta Pokrywczynska1, Jan Adamowicz1, Monika Czapiewska1, Daria Balcerczyk1, Arkadiusz Jundzill1, Maciej Nowacki1, Peter Petros2, Tomasz Drewa1,3.
Abstract
INTRODUCTION: Controversy exists regarding the therapeutic benefit of cell-based therapy in the treatment of stress urinary incontinence (SUI). AREAS COVERED: The aim of this systematic review was to evaluate evidence regarding the therapeutic effect and safety of cell-based therapy in the treatment of SUI and to propose a new approach to SUI treatment utilizing tissue engineering methodologies. We have thoroughly reviewed the literature using PubMed in order to identify only original, clinical studies involving cell therapy for SUI. EXPERT OPINION: Cell-based therapy, as practiced today, is a safe but ineffective method for SUI treatment. The key to an optimal therapeutic outcome in SUI is accurate diagnosis combined with targeted therapy. Targeted therapy in SUI should be based on cell implantation to restore and regenerate the damaged urethral sphincter and/or the construction of a neo-pubourethral ligament utilizing tissue engineering methodologies.Entities:
Keywords: Cell therapy; stem cells; stress urinary incontinence; tissue engineering; tissue-engineered slings
Mesh：
Year: 2015 PMID： 26560683 DOI： 10.1517/14712598.2016.1118459
Source DB: PubMed Journal: Expert Opin Biol Ther ISSN： 1471-2598 Impact factor: 4.388