Pietro Cignini1, Laura Maggio Savasta2, Ferdinando Antonio Gulino3, Salvatore Giovanni Vitale4, Lucia Mangiafico1, Alvaro Mesoraca5, Claudio Giorlandino6. 1. Division of Obstetrics and Gynaecology, Altamedica Main Center, Viale Liegi, 45, Rome, Italy. 2. Division of Obstetrics and Gynaecology, University of Messina, Messina, Italy. 3. Division of Obstetrics and Gynaecology, Department of Surgery, S. Bambino Hospital, University of Catania, Via Torresino, 22, Catania, Italy. docferdi@hotmail.it. 4. Division of Obstetrics and Gynaecology, Department of Surgery, S. Bambino Hospital, University of Catania, Via Torresino, 22, Catania, Italy. 5. Division of Medical Genetics, Altamedica Main Center, Viale Liegi, 45, Rome, Italy. 6. Altamedica Main Center, Viale Liegi, 45, Rome, Italy.
Abstract
PURPOSE: Low levels of plasmatic pregnancy-associated plasma protein-A (PAPP-A) and high levels of free-beta human chorionic gonadotropin (beta-hCG) could influence the outcome of pregnancy. The objective of this study is to assess the correlation between PAPP-A and free beta-hCG and birth weight. MATERIALS AND METHODS: Prospective follow-up study performed on 3332 patients in the first trimester of pregnancy who were subjected to a screening test focused on evaluation of fetal aneuploidy (SCA-TEST). The values of PAPP-A and free beta-hCG were both analyzed as raw values and subsequently converted to a multiple of the median (MoM). Statistical analysis was performed using SPSS version 17.0.1 (SPSS Inc., Chicago, USA). RESULTS: The incidence of "small for gestational age" in patients with PAPP-A MoM <1st and <5th ‰ was statistically significant (12 and 9.8 %; p < 0.0001). Also statistically significant data have been highlighted about free beta MoM > 95th ‰ (7 %; p = 0.03). The values of PAPP-A MoM > 99th ‰ are significantly correlated with an increased risk of "large for gestational age" (16.7 %; p < 0.0001). CONCLUSION: Our study demonstrates that specific values of PAPP-A and free beta-hCG could identify the risk of low or high birth weight since the first trimester of pregnancy.
PURPOSE: Low levels of plasmatic pregnancy-associated plasma protein-A (PAPP-A) and high levels of free-beta human chorionic gonadotropin (beta-hCG) could influence the outcome of pregnancy. The objective of this study is to assess the correlation between PAPP-A and free beta-hCG and birth weight. MATERIALS AND METHODS: Prospective follow-up study performed on 3332 patients in the first trimester of pregnancy who were subjected to a screening test focused on evaluation of fetal aneuploidy (SCA-TEST). The values of PAPP-A and free beta-hCG were both analyzed as raw values and subsequently converted to a multiple of the median (MoM). Statistical analysis was performed using SPSS version 17.0.1 (SPSS Inc., Chicago, USA). RESULTS: The incidence of "small for gestational age" in patients with PAPP-A MoM <1st and <5th ‰ was statistically significant (12 and 9.8 %; p < 0.0001). Also statistically significant data have been highlighted about free beta MoM > 95th ‰ (7 %; p = 0.03). The values of PAPP-A MoM > 99th ‰ are significantly correlated with an increased risk of "large for gestational age" (16.7 %; p < 0.0001). CONCLUSION: Our study demonstrates that specific values of PAPP-A and free beta-hCG could identify the risk of low or high birth weight since the first trimester of pregnancy.
Authors: Manouk L E Hendrix; Judith A P Bons; Roy R G Snellings; Otto Bekers; Sander M J van Kuijk; Marc E A Spaanderman; Salwan Al-Nasiry Journal: Fetal Diagn Ther Date: 2019-05-08 Impact factor: 2.587
Authors: Benito Chiofalo; Antonio Simone Laganà; Alberto Vaiarelli; Valentina Lucia La Rosa; Diego Rossetti; Vittorio Palmara; Gaetano Valenti; Agnese Maria Chiara Rapisarda; Roberta Granese; Fabrizio Sapia; Onofrio Triolo; Salvatore Giovanni Vitale Journal: Biomed Res Int Date: 2017-03-29 Impact factor: 3.411