Shuang Liu1, Yiting Xie2, Anthony P Reeves2. 1. School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA. sl2543@cornell.edu. 2. School of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA.
Abstract
PURPOSE: A fully automated segmentation algorithm, progressive surface resolution (PSR), is presented in this paper to determine the closed surface of approximately convex blob-like structures that are common in biomedical imaging. The PSR algorithm was applied to the cortical surface segmentation of 460 vertebral bodies on 46 low-dose chest CT images, which can be potentially used for automated bone mineral density measurement and compression fracture detection. METHODS: The target surface is realized by a closed triangular mesh, which thereby guarantees the enclosure. The surface vertices of the triangular mesh representation are constrained along radial trajectories that are uniformly distributed in 3D angle space. The segmentation is accomplished by determining for each radial trajectory the location of its intersection with the target surface. The surface is first initialized based on an input high confidence boundary image and then resolved progressively based on a dynamic attraction map in an order of decreasing degree of evidence regarding the target surface location. RESULTS: For the visual evaluation, the algorithm achieved acceptable segmentation for 99.35 % vertebral bodies. Quantitative evaluation was performed on 46 vertebral bodies and achieved overall mean Dice coefficient of 0.939 (with max [Formula: see text] 0.957, min [Formula: see text] 0.906 and standard deviation [Formula: see text] 0.011) using manual annotations as the ground truth. CONCLUSIONS: Both visual and quantitative evaluations demonstrate encouraging performance of the PSR algorithm. This novel surface resolution strategy provides uniform angular resolution for the segmented surface with computation complexity and runtime that are linearly constrained by the total number of vertices of the triangular mesh representation.
PURPOSE: A fully automated segmentation algorithm, progressive surface resolution (PSR), is presented in this paper to determine the closed surface of approximately convex blob-like structures that are common in biomedical imaging. The PSR algorithm was applied to the cortical surface segmentation of 460 vertebral bodies on 46 low-dose chest CT images, which can be potentially used for automated bone mineral density measurement and compression fracture detection. METHODS: The target surface is realized by a closed triangular mesh, which thereby guarantees the enclosure. The surface vertices of the triangular mesh representation are constrained along radial trajectories that are uniformly distributed in 3D angle space. The segmentation is accomplished by determining for each radial trajectory the location of its intersection with the target surface. The surface is first initialized based on an input high confidence boundary image and then resolved progressively based on a dynamic attraction map in an order of decreasing degree of evidence regarding the target surface location. RESULTS: For the visual evaluation, the algorithm achieved acceptable segmentation for 99.35 % vertebral bodies. Quantitative evaluation was performed on 46 vertebral bodies and achieved overall mean Dice coefficient of 0.939 (with max [Formula: see text] 0.957, min [Formula: see text] 0.906 and standard deviation [Formula: see text] 0.011) using manual annotations as the ground truth. CONCLUSIONS: Both visual and quantitative evaluations demonstrate encouraging performance of the PSR algorithm. This novel surface resolution strategy provides uniform angular resolution for the segmented surface with computation complexity and runtime that are linearly constrained by the total number of vertices of the triangular mesh representation.
Authors: Valerie K Reed; Wendy A Woodward; Lifei Zhang; Eric A Strom; George H Perkins; Welela Tereffe; Julia L Oh; T Kuan Yu; Isabelle Bedrosian; Gary J Whitman; Thomas A Buchholz; Lei Dong Journal: Int J Radiat Oncol Biol Phys Date: 2008-09-17 Impact factor: 7.038
Authors: Leon Lenchik; Laura Heacock; Ashley A Weaver; Robert D Boutin; Tessa S Cook; Jason Itri; Christopher G Filippi; Rao P Gullapalli; James Lee; Marianna Zagurovskaya; Tara Retson; Kendra Godwin; Joey Nicholson; Ponnada A Narayana Journal: Acad Radiol Date: 2019-08-10 Impact factor: 3.173
Authors: Sebastiaan R S Arends; Mark H F Savenije; Wietse S C Eppinga; Joanne M van der Velden; Cornelis A T van den Berg; Joost J C Verhoeff Journal: Phys Imaging Radiat Oncol Date: 2022-02-17
Authors: Claudia I Henschke; Rowena Yip; Dorith Shaham; Javier J Zulueta; Samuel M Aguayo; Anthony P Reeves; Artit Jirapatnakul; Ricardo Avila; Drew Moghanaki; David F Yankelevitz Journal: J Thorac Imaging Date: 2021-01 Impact factor: 5.528