| Literature DB >> 26558485 |
Ryuya Fujii1, Yusuke Matsu1, Atsushi Minami1, Shota Nagamine1, Ichiro Takeuchi1, Katsuya Gomi2, Hideaki Oikawa1.
Abstract
To elucidate the general biosynthetic pathway of fungal dimeric anhydrides, a gene cluster for the biosynthesis of the antihy-percholesterolemic agent phomoidride was identified by heterologous expression of candidate genes encoding the highly reducing polyketide synthase, alkylcitrate synthase (ACS), and alkylcitrate dehydratase (ACDH). An in vitro analysis of ACS and ACDH revealed that they give rise to anhydride monomers. Based on the established monomer biosynthesis, we propose a general biogenesis of dimeric anhydrides involving a single donor unit and four acceptor units.Entities:
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Year: 2015 PMID： 26558485 DOI： 10.1021/acs.orglett.5b02934
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005