| Literature DB >> 26558319 |
Maurice A Marsini1, Jonathan T Reeves1, Jean-Nicolas Desrosiers1, Melissa A Herbage1, Jolaine Savoie1, Zhibin Li1, Keith R Fandrick1, C Avery Sader1, Bryan McKibben1, Donghong A Gao1, Jianwen Cui1, Nina C Gonnella1, Heewon Lee1, Xudong Wei1, Frank Roschangar1, Bruce Z Lu1, Chris H Senanayake1.
Abstract
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternary amino esters and derivatives starting from readily available precursors.Entities:
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Year: 2015 PMID： 26558319 DOI： 10.1021/acs.orglett.5b02838
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005