Kentaro Kawabe1, Shinichiro Ochi2, Yuta Yoshino2, Yoko Mori2, Hiroshi Onuma3, Haruhiko Osawa3, Yoshiki Hosoda4, Shu-Ichi Ueno2. 1. Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan. 2. Department of Neuropsychiatry, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan. 3. Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan. 4. Horie Hospital, Matsuyama City, Ehime, Japan.
Abstract
BACKGROUND: Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period. METHODS: The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined. RESULTS: We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total cholesterol and hemoglobin A1c levels, although physical changes such as body mass index and abdominal girth, were not observed. The amount of resistin may not be associated with mental states and physical parameters. CONCLUSIONS: We could not find physical factors related to metabolic changes of antipsychotics in this 2-year study. However, several psychological factors, such as health-related thoughts and behaviors, should be studied in the future.
BACKGROUND: Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipidmetabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period. METHODS: The participants were 68 schizophrenicpatients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined. RESULTS: We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total cholesterol and hemoglobin A1c levels, although physical changes such as body mass index and abdominal girth, were not observed. The amount of resistin may not be associated with mental states and physical parameters. CONCLUSIONS: We could not find physical factors related to metabolic changes of antipsychotics in this 2-year study. However, several psychological factors, such as health-related thoughts and behaviors, should be studied in the future.
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