Daniel J Cox1, Ann G Taylor2, Harsimran Singh3, Matthew Moncrief3, Anne Diamond3, William S Yancy4, Shefali Hegde3, Anthony L McCall5. 1. Center for Behavioral Medicine Research, University of Virginia School of Medicine, PO Box 800223, Charlottesville, VA 22908, USA. Electronic address: djc4f@virginia.edu. 2. University of Virginia School of Nursing, PO Box 800782, Charlottesville, VA 22908, USA. 3. Center for Behavioral Medicine Research, University of Virginia School of Medicine, PO Box 800223, Charlottesville, VA 22908, USA. 4. Duke University School of Medicine, Durham Veterans Affairs Medical Center, 508 Fulton St # 3, Durham, NC 27705, USA. 5. Endocrinology and Metabolism, University of Virginia School of Medicine, PO Box 801407, Charlottesville, VA 22908, USA.
Abstract
AIMS: This preliminary RCT investigated whether an integrated lifestyle modification program that focuses on reducing postprandial blood glucose through replacing high with low glycemic load foods and increasing routine physical activities guided by systematic self-monitoring of blood glucose (GEM) could improve metabolic control of adults with type 2 diabetes mellitus, without compromising other physiological parameters. METHODS:Forty-seven adults (mean age 55.3 years) who were diagnosed with type 2 diabetes mellitus for less than 5 years (mean 2.1 years), had HbA1c ≥ 7% (mean 8.4%) and were not taking blood glucose lowering medications, were randomized to routine care or five 1-h instructional sessions of GEM. Assessments at baseline and 6 months included a physical exam, metabolic and lipid panels, and psychological questionnaires. RESULTS: The GEM intervention led to significant improvements in HbA1c (decreasing from 8.4 to 7.4% [69-57 mmol/mol] compared with 8.3 to 8.3% [68-68 mmol/mol] for routine care; Interaction p<.01) and psychological functioning without compromising other physiological parameters. CONCLUSIONS: Consistent with a patient-centered approach, GEM appears to be an effective lifestyle modification option for adults recently diagnosed with type 2 diabetes mellitus.
RCT Entities:
AIMS: This preliminary RCT investigated whether an integrated lifestyle modification program that focuses on reducing postprandial blood glucose through replacing high with low glycemic load foods and increasing routine physical activities guided by systematic self-monitoring of blood glucose (GEM) could improve metabolic control of adults with type 2 diabetes mellitus, without compromising other physiological parameters. METHODS: Forty-seven adults (mean age 55.3 years) who were diagnosed with type 2 diabetes mellitus for less than 5 years (mean 2.1 years), had HbA1c ≥ 7% (mean 8.4%) and were not taking blood glucose lowering medications, were randomized to routine care or five 1-h instructional sessions of GEM. Assessments at baseline and 6 months included a physical exam, metabolic and lipid panels, and psychological questionnaires. RESULTS: The GEM intervention led to significant improvements in HbA1c (decreasing from 8.4 to 7.4% [69-57 mmol/mol] compared with 8.3 to 8.3% [68-68 mmol/mol] for routine care; Interaction p<.01) and psychological functioning without compromising other physiological parameters. CONCLUSIONS: Consistent with a patient-centered approach, GEM appears to be an effective lifestyle modification option for adults recently diagnosed with type 2 diabetes mellitus.
Authors: Daniel J Cox; Kun Fang; Anthony L McCall; Mark R Conaway; Tom A Banton; Matthew A Moncrief; Anne M Diamond; Ann G Taylor Journal: Diabetes Ther Date: 2018-12-18 Impact factor: 2.945
Authors: Daniel J Cox; Tom Banton; Matthew Moncrief; Mark Conaway; Anne Diamond; Viola Holmes; Joyce Green Pastors; Anne Wolf; Kun Fang; Anthony McCall Journal: BMJ Open Diabetes Res Care Date: 2020-12