Literature DB >> 2655594

Endothelin stimulates aldosterone biosynthesis by dispersed rabbit adreno-capsular cells.

R Morishita1, J Higaki, T Ogihara.   

Abstract

The effect of endothelin on aldosterone production by dispersed adreno-capsular cells from rabbits was examined. Porcine endothelin stimulated aldosterone production dose-dependently with an EC50 of 5 x 10(-14) M, but had no effect on corticosterone production. A calcium channel blocker, nicardipine, completely inhibited the stimulatory effect of endothelin on aldosterone production. Endothelin induced prompt and sustained increase in intracellular Ca2+ in fura-2-loaded cells, and nicardipine inhibited this increase in intracellular Ca2+. These results indicate that endothelin stimulates aldosterone biosynthesis in dispersed zona glomerulosa cells of rabbits, and that its effects is related to increase in intracellular calcium through voltage-dependent calcium channels.

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Year:  1989        PMID： 2655594     DOI： 10.1016/0006-291x(89)92479-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

Review 1.  Endothelin A receptor antagonists in congestive heart failure: blocking the beast while leaving the beauty untouched?

Authors:  L E Spieker; G Noll; F T Ruschitzka; T F Lüscher
Journal:  Heart Fail Rev       Date:  2001-12       Impact factor: 4.214

Review 2.  Regulation of blood pressure and salt homeostasis by endothelin.

Authors:  Donald E Kohan; Noreen F Rossi; Edward W Inscho; David M Pollock
Journal:  Physiol Rev       Date:  2011-01       Impact factor: 37.312

3.  Characterization of endothelin receptors on a human neuroblastoma cell line: evidence for the ETA subtype.

Authors:  L C Wilkes; M R Boarder
Journal:  Br J Pharmacol       Date:  1991-11       Impact factor: 8.739

4.  Inositol phosphate release and steroidogenesis in rat adrenal glomerulosa cells. Comparison of the effects of endothelin, angiotensin II and vasopressin.

Authors:  E A Woodcock; P J Little; J K Tanner
Journal:  Biochem J       Date:  1990-11-01       Impact factor: 3.857

5.  Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.

Authors:  Bradley A Maron; Ying-Yi Zhang; Kevin White; Stephen Y Chan; Diane E Handy; Christopher E Mahoney; Joseph Loscalzo; Jane A Leopold
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6.  Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex.

Authors:  G Rossi; G Albertin; A Belloni; L Zanin; M A Biasolo; T Prayer-Galetti; M Bader; G G Nussdorfer; G Palù; A C Pessina
Journal:  J Clin Invest       Date:  1994-09       Impact factor: 14.808

7.  Endothelin as an autocrine factor in the regulation of parathyroid cells.

Authors:  Y Fujii; J E Moreira; C Orlando; M Maggi; G D Aurbach; M L Brandi; K Sakaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

8.  Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings.

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9.  Structure of six-transmembrane cation channels revealed by single-particle analysis from electron microscopic images.

Authors:  Kazuhiro Mio; Toshihiko Ogura; Chikara Sato
Journal:  J Synchrotron Radiat       Date:  2008-04-18       Impact factor: 2.616

10.  Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1.

Authors:  Xuefang Pan; Lubov Grigoryeva; Volkan Seyrantepe; Junzheng Peng; Katrin Kollmann; Johanne Tremblay; Julie L Lavoie; Aleksander Hinek; Torben Lübke; Alexey V Pshezhetsky
Journal:  PLoS Genet       Date:  2014-02-27       Impact factor: 5.917
  10 in total

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