Literature DB >> 2655587

Cellular and molecular biology of Alzheimer's disease.

D L Price, E H Koo, A Unterbeck.   

Abstract

Alzheimer's disease results from the degeneration of neurons. Degenerating nerve cells express atypical proteins, and amyloid is deposited. We suggest that some of these events are strongly influenced by genetic factors and age. Animal models should be useful in investigating the pathogenic mechanisms that lead to the brain abnormalities seen in this disease.

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Year:  1989        PMID： 2655587     DOI： 10.1002/bies.950100208

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  6 in total

1.  Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

Authors:  E H Koo; S S Sisodia; D R Archer; L J Martin; A Weidemann; K Beyreuther; P Fischer; C L Masters; D L Price
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

2.  The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity.

Authors:  C A Pardo; L J Martin; J C Troncoso; D L Price
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

3.  Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

Authors:  H Arai; V M Lee; L Otvos; B D Greenberg; D E Lowery; S K Sharma; M L Schmidt; J Q Trojanowski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

4.  Molecular features of hypothalamic plaques in Alzheimer's disease.

Authors:  D G Standaert; V M Lee; B D Greenberg; D E Lowery; J Q Trojanowski
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

5.  Regulatory region of human amyloid precursor protein (APP) gene promotes neuron-specific gene expression in the CNS of transgenic mice.

Authors:  D O Wirak; R Bayney; C A Kundel; A Lee; G A Scangos; B D Trapp; A J Unterbeck
Journal:  EMBO J       Date:  1991-02       Impact factor: 11.598

6.  Memantine combined with environmental enrichment improves spatial memory and alleviates Alzheimer's disease-like pathology in senescence-accelerated prone-8 (SAMP8) mice.

Authors:  Jingde Dong; Mi Zhou; Xiaoqiang Wu; Mingyang Du; Xiaoshan Wang
Journal:  J Biomed Res       Date:  2012-10-15
  6 in total

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