Literature DB >> 26555790

Copper-Catalyzed Direct C2-Benzylation of Indoles with Alkylarenes.

Hui-Jun Zhang1, Feng Su1, Ting-Bin Wen1.   

Abstract

The copper-catalyzed regioselective cross-dehydrogenative coupling of N-pyrimidylindoles with benzylic C(sp(3))-H bonds has been developed. Di-tert-butyl peroxide was employed as a mild oxidant, and benzaldehyde proved to be an effective additive. This reaction provides a direct and pratical route to a variety of 2-benzylindoles.

Entities:  

Year:  2015        PMID： 26555790     DOI： 10.1021/acs.joc.5b01935

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Aqueous Benzylic C-H Trifluoromethylation for Late-Stage Functionalization.

Authors:  Shuo Guo; Deyaa I AbuSalim; Silas P Cook
Journal:  J Am Chem Soc       Date:  2018-09-24       Impact factor: 15.419

2.  Cation-π Interactions in the Benzylic Arylation of Toluenes with Bimetallic Catalysts.

Authors:  Sheng-Chun Sha; Sergei Tcyrulnikov; Minyan Li; Bowen Hu; Yue Fu; Marisa C Kozlowski; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2018-09-19       Impact factor: 15.419

3.  Copper-mediated construction of benzothieno[3,2-b]benzofurans by intramolecular dehydrogenative C-O coupling reaction.

Authors:  Liankun Ai; Ibrahim Yusuf Ajibola; Baolin Li
Journal:  RSC Adv       Date:  2021-11-10       Impact factor: 4.036
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.