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Literature DB >> 2655531

Enhanced gentamicin killing of Escherichia coli by tet gene expression.

T L Merlin¹, D L Corvo, J H Gill, J K Griffith.

Abstract

Time-kill studies were performed to determine the effect of tetracycline resistance (tet) gene expression on gentamicin killing of Escherichia coli. Expression of tet increased gentamicin killing in laboratory strains and clinical isolates. A role for tetracycline in inducing tet expression and increasing the bactericidal activity of aminoglycosides is suggested.

Entities: Chemical Species

Mesh：

Substances：
Gentamicins

Year: 1989 PMID： 2655531 PMCID： PMC171462 DOI： 10.1128/AAC.33.2.230

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

5 in total

Review 1. Aminoglycoside research 1975-1985: prospects for development of improved agents.

Authors: K E Price
Journal: Antimicrob Agents Chemother Date: 1986-04 Impact factor: 5.191

Review 2. Role of pharmacokinetics in the outcome of infections.

Authors: G L Drusano
Journal: Antimicrob Agents Chemother Date: 1988-03 Impact factor: 5.191

3. Studies on antibiotic synergism against enterococci. I. Bacteriologic studies.

Authors: R C Moellering; C Wennersten; A N Weinberg
Journal: J Lab Clin Med Date: 1971-05

4. An N-terminal domain of the tetracycline resistance protein increases susceptibility to aminoglycosides and complements potassium uptake defects in Escherichia coli.

Authors: J K Griffith; T Kogoma; D L Corvo; W L Anderson; A L Kazim
Journal: J Bacteriol Date: 1988-02 Impact factor: 3.490

5. Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin.

Authors: S H Powell; W L Thompson; M A Luthe; R C Stern; D A Grossniklaus; D D Bloxham; D L Groden; M R Jacobs; A O DiScenna; H A Cash; J D Klinger
Journal: J Infect Dis Date: 1983-05 Impact factor: 5.226

5 in total

Enhanced gentamicin killing of Escherichia coli by tet gene expression.

Review 1. Aminoglycoside research 1975-1985: prospects for development of improved agents.

Review 2. Role of pharmacokinetics in the outcome of infections.

3. Studies on antibiotic synergism against enterococci. I. Bacteriologic studies.

4. An N-terminal domain of the tetracycline resistance protein increases susceptibility to aminoglycosides and complements potassium uptake defects in Escherichia coli.

5. Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin.

Review 1. Multidrug evolutionary strategies to reverse antibiotic resistance.

2. Effects of production of abnormal proteins on the rate of killing of Escherichia coli by streptomycin.

3. Potentiation by salicylate and salicyl alcohol of cadmium toxicity and accumulation in Escherichia coli.

4. Aminoglycoside uptake increased by tet gene expression.

5. MexXY multidrug efflux system of Pseudomonas aeruginosa.