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Literature DB >> 26554303

IQGAP1 is a phosphoinositide effector and kinase scaffold.

Abstract

Phosphatidylinositol 4,5-bisphosphate (PI4,5P2) is a lipid messenger that regulates a wide variety of cellular functions. The majority of cellular PI4,5P2 is generated by isoforms of the type I phosphatidylinositol phosphate kinases (PIPKI) that are generated from three genes, and each PIPKI isoform has a unique distribution and function in cells. It has been shown that the signaling specificity of PI4,5P2 can be determined by a physical association of PIPKs with PI4,5P2 effectors. IQGAP1 is newly identified as an interactor of multiple isoforms of PIPKs. Considering the versatile roles of IQGAP1 in cellular signaling pathways, IQGAP1 may confer isoform-specific roles of PIPKs in distinct cellular locations. In this mini review, the emerging roles of PIPKs that are regulated by an association with IQGAP1 will be summarized. Focuses will be on cell migration, vesicle trafficking, cell signaling, and nuclear events.

Entities: Chemical Disease Gene Mutation Species

Keywords: Cell signaling; IQGAP; Phosphatidylinositol phosphate kinase; Phosphoinositide

Mesh：

Substances：

Year: 2015 PMID： 26554303 PMCID： PMC4729663 DOI： 10.1016/j.jbior.2015.10.004

Source DB: PubMed Journal: Adv Biol Regul ISSN： 2212-4926

75 in total

1. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.

Authors: Yanyun Xie; Judy Yan; Jean-Claude Cutz; Adrian P Rybak; Lizhi He; Fengxiang Wei; Anil Kapoor; Valentina A Schmidt; Lijian Tao; Damu Tang
Journal: Biochim Biophys Acta Date: 2012-03-02

2. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.

Authors: Mauro Sbroggiò; Daniela Carnevale; Alessandro Bertero; Giuseppe Cifelli; Emanuele De Blasio; Giada Mascio; Emilio Hirsch; Wadie F Bahou; Emilia Turco; Lorenzo Silengo; Mara Brancaccio; Giuseppe Lembo; Guido Tarone
Journal: Cardiovasc Res Date: 2011-04-14 Impact factor: 10.787

3. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.

Authors: Mauro Sbroggiò; Alessandro Bertero; Silvia Velasco; Federica Fusella; Emanuele De Blasio; Wadie F Bahou; Lorenzo Silengo; Emilia Turco; Mara Brancaccio; Guido Tarone
Journal: J Cell Sci Date: 2011-10-15 Impact factor: 5.285

Review 4. Life at the leading edge.

Authors: Anne J Ridley
Journal: Cell Date: 2011-06-24 Impact factor: 41.582

5. Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.

Authors: Narendra Thapa; Yue Sun; Mark Schramp; Suyong Choi; Kun Ling; Richard A Anderson
Journal: Dev Cell Date: 2012-01-17 Impact factor: 12.270

6. Star-PAP control of BIK expression and apoptosis is regulated by nuclear PIPKIα and PKCδ signaling.

Authors: Weimin Li; Rakesh S Laishram; Zhe Ji; Christy A Barlow; Bin Tian; Richard A Anderson
Journal: Mol Cell Date: 2012-01-13 Impact factor: 17.970

7. Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.

Authors: Raymond D Blind; Miyuki Suzawa; Holly A Ingraham
Journal: Sci Signal Date: 2012-06-19 Impact factor: 8.192

8. A conserved role of IQGAP1 in regulating TOR complex 1.

Authors: Yemsrach K Tekletsadik; Robert Sonn; Mahasin A Osman
Journal: J Cell Sci Date: 2012-02-10 Impact factor: 5.285

9. IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.

Authors: Miles J Dixon; Alexander Gray; Martijn Schenning; Mark Agacan; Wolfram Tempel; Yufeng Tong; Lyudmila Nedyalkova; Hee-Won Park; Nicholas R Leslie; Daan M F van Aalten; C Peter Downes; Ian H Batty
Journal: J Biol Chem Date: 2012-04-05 Impact factor: 5.157

10. PIP2 signaling, an integrator of cell polarity and vesicle trafficking in directionally migrating cells.

Authors: Narendra Thapa; Richard A Anderson
Journal: Cell Adh Migr Date: 2012-09-01 Impact factor: 3.405

21 in total

Review 1. New model for the interaction of IQGAP1 with CDC42 and RAC1.

Authors: Kazem Nouri; David J Timson; Mohammad R Ahmadian
Journal: Small GTPases Date: 2017-06-19

2. Ca²⁺-Dependent Switch of Calmodulin Interaction Mode with Tandem IQ Motifs in the Scaffolding Protein IQGAP1.

Authors: Mingzhen Zhang; Zhigang Li; Hyunbum Jang; Andrew C Hedman; David B Sacks; Ruth Nussinov
Journal: Biochemistry Date: 2019-11-26 Impact factor: 3.162

3. IQGAP1 scaffolding links phosphoinositide kinases to cytoskeletal reorganization.

Authors: V Siddartha Yerramilli; Alonzo H Ross; Suzanne Scarlata; Arne Gericke
Journal: Biophys J Date: 2022-01-22 Impact factor: 4.033

Review 4. Phosphoinositide 3-kinase pathways and autophagy require phosphatidylinositol phosphate kinases.

Authors: Suyong Choi; Xander Houdek; Richard A Anderson
Journal: Adv Biol Regul Date: 2018-02-08

5. Phosphatidic acid generated by PLD2 promotes the plasma membrane recruitment of IQGAP1 and neointima formation.

Authors: Ziqing Wang; Ming Cai; Li Wei Rachel Tay; Feng Zhang; Ping Wu; Anh Huynh; Xiumei Cao; Gilbert Di Paolo; Junmin Peng; Dianna M Milewicz; Guangwei Du
Journal: FASEB J Date: 2019-02-27 Impact factor: 5.834

6. IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Authors: Kazem Nouri; Eyad K Fansa; Ehsan Amin; Radovan Dvorsky; Lothar Gremer; Dieter Willbold; Lutz Schmitt; David J Timson; Mohammad R Ahmadian
Journal: J Biol Chem Date: 2016-11-04 Impact factor: 5.157