| Literature DB >> 26554163 |
Xianbo Mou, Taotao Li, Jiuhai Wang, Zeeshan Ali, Yuanying Zhang, Zhu Chen, Yan Deng, Song Li, Enben Su, Qiongying Jia, Nongyue He, Jian Ni, Daxiang Cui.
Abstract
With the help of Fe3O4 nagnetic nanoparticles as a solid carrier and an excellent tool for separation, six SNP loci (rs2279115 of BCL2 gene, rs804270 of NEIL2 gene, rs909253 of LTA gene, rs2294008 of PSCA gene, rs3765524 and rs10509670 of PLCE1 gene) were selected to evaluate their relation to gastric cancer risk. Using two kinds of functionalized magnetic nanoparticles and universal tagged arrays, the whole operation procedure including genome DNA extraction and SNP genotyping was performed. All genotypes and allele frequencies were calculated in the cases and controls respectively to analyze their association with gastric cancer risk. Totally 200 pathological samples and 134 normal control subjects were collected. The results demonstrated that four SNP loci (rs2279115, rs804270, rs909253 and rs3765524) showed a potential association with gastric cancer risk, and the other two (rs2294008, rs10509670) possessed no difference/association among cases and controls.Entities:
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Year: 2015 PMID： 26554163 DOI： 10.1166/jbn.2015.2113
Source DB: PubMed Journal: J Biomed Nanotechnol ISSN： 1550-7033 Impact factor: 4.099