J David Spence1, Brian L Rayner2. 1. From the Divisions of Neurology and Clinical Pharmacology, Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada (J.D.S.); and Division of Nephrology and Hypertension, Groote Schuur Hospital, Cape Town University, Cape Town, South Africa (B.L.R.). dspence@robarts.ca. 2. From the Divisions of Neurology and Clinical Pharmacology, Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada (J.D.S.); and Division of Nephrology and Hypertension, Groote Schuur Hospital, Cape Town University, Cape Town, South Africa (B.L.R.).