Literature DB >> 26553045

Erratum to: Development of the Post Cardiac Surgery (POCAS) prognostic score.

Eduardo Tamayo1, Inma Fierro2, Juan Bustamante-Munguira3, María Heredia-Rodríguez1, Pablo Jorge-Monjas1, Laura Maroto4, Esther Gómez-Sánchez1, Francisco Jesús Bermejo-Martín5, Francisco Javier Álvarez2, José Ignacio Gómez-Herreras1.   

Abstract

Entities:  

Year:  2015        PMID: 26553045      PMCID: PMC4638080          DOI: 10.1186/s13054-015-1117-0

Source DB:  PubMed          Journal:  Crit Care        ISSN: 1364-8535            Impact factor:   9.097


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After Publication of the original article [1] it has been brought to our attention that none of the tables referred to in the text have been included in the article. Tables 1, 2, 3, 4, 5, 6 and 7 are now displayed below.
Table 1

Patient population profile (Survivors and non-survivors)

VariableSurvivors (N = 829)Non survivors (N = 80) P value
Preoperative factors
 Age, years66.3 ± 11.268.9 ± 11.3 0.05
 Sex, M/F male gender574 (69.2)48 (60)0.09
 Peso, kg72.7 ± 1571.9 ± 11.40.69
 Talla, cm163.3 ± 9162.3 ± 8.90.34
 Hypertension449 (54.2)50 (62.5)0.15
 Atrial fibrillation167 (20.1)23 (28.8)0.07
 Diabetes mellitus198 (23.9)20 (25)0.82
 Obesity132 (15.9)12 (15)0.82
 Smoking114 (13.8)6 (7.5)0.11
 Drinking alcohol50 (6)2 (2.5)0.19
 Hepatic disease23 (2.8)3 (3.8)0.61
 Respiratory disease93 (11.2)15(18.8) 0.04
 Chronic renal failure50 (6)11 (13.8) 0.008
 Immunosuppression23 (2.8)4 (5.0)0.26
 Previous cardiac surgery79 (9.5)11 (13.8)0.61
 Emergent surgery70 (8.4)23 (28.8) 0.0001
Perioperative factors
 Left ventricle ejection fraction56.8 ± 11.549.6 ± 13.6 0.0001
 Valve455 (54.9)47 (58.8)0.5
 CABG399 (48.1)39 (48.8)0.91
 Valve + CABG109 (13.1)20 (25.0) 0.004
 Total CPB time. min105.3 ± 44.29156.1 ± 77.7 0.0001
 Aortic cross-clamp time, min77.3 ± 37.04106.9 ± 56.7 0.0001
Postoperative value
 Duration of mechanical ventilation, days25.23 ± 62.5919.75 ± 31.430.81
 Reintubation25 (3)16 (20) 0.0001
 Politrasfusion254 (30.6)25 (31.3)0.640
 Acute renal failure67 (8.1)36 (45.0) 0.0001
 Reintervención21 (2.5)13 (16.3) 0.0001
 Intra-aortic balloon pump32 (3.9)27 (33.8) 0.0001
 Pneumonia35 (4.2)15 (18.8) 0.0001
 Surgical site infections25 (3)1 (1.3)0.36
 Preoperative hospitalization, days18.2 ± 15.510.6 ± 11.3 0.0001
 Mean ICU stay, days4.7 ± 12.114.3 ± 20.9 0.0001
 Duration of hospitalization after surgery, days22.8 ± 20.924.9 ± 23.70.43
Risk score
 Additive EuroSCORE, points4.5 ± 2.87.4 ± 4.5 0.0001
 Logistic EuroSCORE, points5.4 ± 6.216.7 ± 18.5 0.0001
 ACEF score, points1.2 ± 0.41.7 ± 0.6 0.0001
 SOFA score, points5.5 ± 1.77.7 ± 1.7 0.0001
 SAP II score, points28.9 ± 8.743.0 ± 11.6 0.0001
 APACHE II score, points13.3 ± 3.818.3 ± 5.6 0.0001

Values are expressed as numbers (n), percentages (%), and means ± SD

APACHE II Acute Physiology and Chronic Health Evaluation II, CABG coronary artery bypass graft, CPB cardiopulmonary bypass

Table 2

Parameters at the admission to the intensive care unit in survivors and non-survivors

VariableSurvivors (n = 829)Non-survivors (n = 80) p value
pH7.37 ± 0.067.31 ± 0.9 0.0001
HCO3 mEq/l24.4 ± 3.1521.04 ± 3.9 0.0001
PCO2, mmHg41.0 ± 6.341.3 ± 6.20.69
PaO2/FiO2, range245.6 ± 72.8226.2 ± 77.1 0.024
Core temperature, °C36.6 ± 0.836.7 ± 1.50.22
Leukocyte count, cells/mm3 10535.1 ± 6396.813454.8 ± 5727.4 0.0001
C-reactive protein, mg/L14.3 ± 35.129.5 ± 53.1 0.014
Procalcitonin, ng/mL0.8 ± 4.93.1 ± 5. 0.0001
Lactates, mmol/L29.4 ± 14.963.6 ± 43.7 0.0001
ScvO2, %73.4 ± 8.665.6 ± 12.3 0.0001
Heart rate, beats/min92.3 ± 18.5109.7 ± 17.2 0.0001
Mean arterial pressure, mmHg72.5 ± 13.753.6 ± 10.5 0.0001
Glucose, mg/dl181 ± 57.2193.7 ± 70.50.13
Creatinine, mg/dl1 ± 0.51.5 ± 1.3 0.001
Hematocrit, %29.1 ± 4.428 ± 4.5 0.04
Na, mmol/L140.1 ± 7.6142 ± 4.8 0.028
K, mmol/L3.9 ± 0.64 ± 0.70.47
TnT, μg/l0.8 ± 1.43.8 ± 6.1 0.0001
CK-MB, ng/mL336.4 ± 283.2161.6 ± 186.4 0.0001
INR, range1.5 ± 0.22 ± 0.8 0.0001
aPTTr, range1.2 ± 0.31.8 ± 1.2 0.0001
Platelet count, cells/mm3 119490.8 ± 47226.4119898.7 ± 65476.30.95

Values are expressed as means ± SD

aPTTr activated partial thromboplastin time ratio, CK-MB creatine kinase-MB, INR international normalized ratio, K potassium, Na sodium, PaO2/FiO2 ratio ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, PCO partial pressure of carbon dioxide, ScvO2 central venous oxygen saturation, TnT troponin T

Table 3

Logistic regression model: risk factors for 90-day In-Hospital Mortality

BSE p valueOR95 % CI
Constant−11.5611.1550.00010.0001
1000/MAP (mmHg)0.3080.0460.00011.3601.242–1.489
1000/Bicarbonate (mEq/L)0.0340.0130.0111.0351.008–1.062
Lactate (mg/dL)0.0220.0070.0011.0231.009–1.036
INR1.0250.3970.01012.7881.282–6.064

Hosmer-Lemeshow 2 = 8.62; P = .37. Multicollinearity diagnostics: 1000/MAP, 0.78 tolerance; 1000/Bicarbonate, 0.87 tolerance; Lactate, 0.64 tolerance and INR, 0.65 tolerance

B regression coefficient, CI confidence interval, INR international normalized ratio, MAP Mean arterial pressure, OR Odds Ratio

Table 4

A new system to predict operative mortality in patients undergoing cardiac surgery: POCAS score

Lactate (mmol/L)ScoreINRScore
 <16.003<1.3112
 16.00 to 24.9041.31 to 1.5214
 25.00 to 34.9061.53 to 1.9416
 35.00 to 52.9091.95 to 2.6520
 53.00 to 79.0014>2.6530
 >79.0021
MAP (mm Hg)ScoreBicarbonate (mEq/L)Score
 >7535>27.414
 69 to 754125.7 to 27.415
 61 to 684624.1 to 25.616
 605022.8 to 24.017
 45 to 595820.4 to 22.718
 <457514.6 to 20.322
<14.635
Table 5

Development series: predictive function of POCAS score scale for 90-day In- Hospital Mortality (Logistic regression)

BSE p valueOR95 % CI
POCAS0.1130.0110.00011.1191.0961.143
Constant−12.6711.0510.00010.000

B regression coefficient, CI confidence interval, OR Odds Ratio

Table 6

Operative risk categories with corresponding cumulative risk score for 90-day In-Hospital Mortality after cardiac surgery for the risk groups calculated from the roc curve, cumulative risk score*

Risk scoreObserved no.Predicted no.% probability (95 % CI)90-Day In-Hospital Mortality (%)Operative risk categories% probability (95 % CI)
<75110.92 (0.89–0.95)0.4Low2.33 (2.19–2.46)
75–81332.10 (2.03–2.16)1.5
82–9011114.82 (4.62–5.02)6.1
91–100121212.99 (12.34–13.65)11.1Medium16.32 (15.25–17.38)
101–105111025.53 (24.40–26.66)28.2
106–128292856.22 (51.86–60.58)55.8High56.22 (51.86–60.58)
>128131394.98 (92.75–97.21)100.0Very high94.98 (92.75–97.21)

CI confidence interval, n number

Table 7

Validity of Additive EuroSCORE, Logistic EuroSCORE, ACEF, SOFA, SAP II, APACHE II, and POCAS to predict the 90-day In-Hospital Mortality rate after cardiac surgery with CEC

Criterion for assigning a mortalityAUC [95 % IC]Ind.Youden MáxCutoff valueSensitivitySpecifityNPVPPV Χ 2 test AUCs (other scale*POCAS)
POCAS0.899 [0.864–0.934]*0.6385.50.910.7298.724.9--
APACHE II0.768 [0.709–0.828]*0.4217.50.540.8895.230.720.42*
SOFA0.825 [0.782–0.867]*0.525.50.920.5998.718.810.16**
SAPS II0.847 [0.800–0.893]*0.5632.50.850.7198.220.124.10*
ACEF0.699 [0.639–0.758]*0.311.490.500.8193.522.3652.30*
Logistic EuroSCORE0.754 [0.693–0.814]*0.404.110.810.5896.717.3398.28*
Additive EuroSCORE0.714 [0.647–0.780]*0.385.500.710.6795.419.230.39*

(*) p < 0.0001; (**) p < 0.05

AUC area under the curve, NPV negative predictive value, PPV positive predictive value, SOFA Secuencial Organ Failure Assesment, SAP II Simplified Acute Physiology Score II, APACHE II Acute Physiology and Chronic Health Evaluation II

Patient population profile (Survivors and non-survivors) Values are expressed as numbers (n), percentages (%), and means ± SD APACHE II Acute Physiology and Chronic Health Evaluation II, CABG coronary artery bypass graft, CPB cardiopulmonary bypass Parameters at the admission to the intensive care unit in survivors and non-survivors Values are expressed as means ± SD aPTTr activated partial thromboplastin time ratio, CK-MB creatine kinase-MB, INR international normalized ratio, K potassium, Na sodium, PaO2/FiO2 ratio ratio of partial pressure of arterial oxygen to fraction of inspired oxygen, PCO partial pressure of carbon dioxide, ScvO2 central venous oxygen saturation, TnT troponin T Logistic regression model: risk factors for 90-day In-Hospital Mortality Hosmer-Lemeshow 2 = 8.62; P = .37. Multicollinearity diagnostics: 1000/MAP, 0.78 tolerance; 1000/Bicarbonate, 0.87 tolerance; Lactate, 0.64 tolerance and INR, 0.65 tolerance B regression coefficient, CI confidence interval, INR international normalized ratio, MAP Mean arterial pressure, OR Odds Ratio A new system to predict operative mortality in patients undergoing cardiac surgery: POCAS score Development series: predictive function of POCAS score scale for 90-day In- Hospital Mortality (Logistic regression) B regression coefficient, CI confidence interval, OR Odds Ratio Operative risk categories with corresponding cumulative risk score for 90-day In-Hospital Mortality after cardiac surgery for the risk groups calculated from the roc curve, cumulative risk score* CI confidence interval, n number Validity of Additive EuroSCORE, Logistic EuroSCORE, ACEF, SOFA, SAP II, APACHE II, and POCAS to predict the 90-day In-Hospital Mortality rate after cardiac surgery with CEC (*) p < 0.0001; (**) p < 0.05 AUC area under the curve, NPV negative predictive value, PPV positive predictive value, SOFA Secuencial Organ Failure Assesment, SAP II Simplified Acute Physiology Score II, APACHE II Acute Physiology and Chronic Health Evaluation II
  1 in total

1.  Development of the Post Cardiac Surgery (POCAS) prognostic score.

Authors:  Eduardo Tamayo; Inma Fierro; Juan Bustamante-Munguira; María Heredia-Rodríguez; Pablo Jorge-Monjas; Laura Maroto; Esther Gómez-Sánchez; Francisco Bermejo-Martín; Francisco Alvarez; José Gómez-Herreras
Journal:  Crit Care       Date:  2013-09-24       Impact factor: 9.097

  1 in total

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