Clémence M Canivet1, Rodolphe Anty2, Stéphanie Patouraux3, Marie-Christine Saint-Paul4, Cynthia Lebeaupin5, Philippe Gual5, Jean-Charles Duclos-Vallee6, Albert Tran1. 1. University Hospital of Nice, Digestive Centre, Nice, France; National Institute of Health and Medical Research (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, France; University of Nice-Sophia-Antipolis, College of Medicine, Nice, France. 2. University Hospital of Nice, Digestive Centre, Nice, France; National Institute of Health and Medical Research (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, France; University of Nice-Sophia-Antipolis, College of Medicine, Nice, France. Electronic address: anty.r@chu-nice.fr. 3. University Hospital of Nice, Digestive Centre, Nice, France; University of Nice-Sophia-Antipolis, College of Medicine, Nice, France; University Hospital of Nice, Biological Center, Nice, France. 4. University Hospital of Nice, Biological Center, Nice, France. 5. National Institute of Health and Medical Research (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, France; University of Nice-Sophia-Antipolis, College of Medicine, Nice, France. 6. Hepato-biliary Centre, Paul Brousse, Villejuif, DHU Hepatinov, France.
Abstract
BACKGROUND: Immunoglobulin G4-related disease is a multi-systemic autoimmune disease. The sole involvement of the liver has been recently reported in Japanese patients and named "immunoglobulin G4-associated autoimmune hepatitis". AIM: To examine the baseline and the 2-year follow-up characteristics of non-Asian patients with immunoglobulin G4-associated autoimmune hepatitis compared to patients with classical autoimmune hepatitis. METHODS: This was a retrospective study of patients who had undergone liver biopsy between March 2009 and January 2012 before starting any treatment. All patients were treated according to the guidelines. Immunoglobulin G4-associated autoimmune hepatitis was diagnosed according to Umemura's histological definition: at least 10 positive immunoglobulin G4-plasma cells per high power field. RESULTS: Among 28 enrolled patients (males 39%, median age 54 years): 7 had immunoglobulin G4-associated autoimmune hepatitis (25%) and 21 had classical hepatitis; fibrosis and activity stages were F1: 57%, F2: 11%, F3: 11%, F4: 21% and A1: 18%, A2: 39%, A3: 43%. Alanine aminotransferase (ALT) activity and serum immunoglobulin G levels were similar in the two groups at baseline and at 2 years. Complete biochemical response (normal ALT) was similar in immunoglobulin G4-associated autoimmune hepatitis and classical hepatitis (67% vs. 59% at 2 years, p=0.74). CONCLUSION: Immunoglobulin G4-associated autoimmune hepatitis has been observed in Western patients and seems to evolve in a similar manner to classical hepatitis.
BACKGROUND: Immunoglobulin G4-related disease is a multi-systemic autoimmune disease. The sole involvement of the liver has been recently reported in Japanese patients and named "immunoglobulin G4-associated autoimmune hepatitis". AIM: To examine the baseline and the 2-year follow-up characteristics of non-Asian patients with immunoglobulin G4-associated autoimmune hepatitis compared to patients with classical autoimmune hepatitis. METHODS: This was a retrospective study of patients who had undergone liver biopsy between March 2009 and January 2012 before starting any treatment. All patients were treated according to the guidelines. Immunoglobulin G4-associated autoimmune hepatitis was diagnosed according to Umemura's histological definition: at least 10 positive immunoglobulin G4-plasma cells per high power field. RESULTS: Among 28 enrolled patients (males 39%, median age 54 years): 7 had immunoglobulin G4-associated autoimmune hepatitis (25%) and 21 had classical hepatitis; fibrosis and activity stages were F1: 57%, F2: 11%, F3: 11%, F4: 21% and A1: 18%, A2: 39%, A3: 43%. Alanine aminotransferase (ALT) activity and serum immunoglobulin G levels were similar in the two groups at baseline and at 2 years. Complete biochemical response (normal ALT) was similar in immunoglobulin G4-associated autoimmune hepatitis and classical hepatitis (67% vs. 59% at 2 years, p=0.74). CONCLUSION: Immunoglobulin G4-associated autoimmune hepatitis has been observed in Western patients and seems to evolve in a similar manner to classical hepatitis.
Authors: J-Matthias Löhr; Ulrich Beuers; Miroslav Vujasinovic; Domenico Alvaro; Jens Brøndum Frøkjær; Frank Buttgereit; Gabriele Capurso; Emma L Culver; Enrique de-Madaria; Emanuel Della-Torre; Sönke Detlefsen; Enrique Dominguez-Muñoz; Piotr Czubkowski; Nils Ewald; Luca Frulloni; Natalya Gubergrits; Deniz Guney Duman; Thilo Hackert; Julio Iglesias-Garcia; Nikolaos Kartalis; Andrea Laghi; Frank Lammert; Fredrik Lindgren; Alexey Okhlobystin; Grzegorz Oracz; Andrea Parniczky; Raffaella Maria Pozzi Mucelli; Vinciane Rebours; Jonas Rosendahl; Nicolas Schleinitz; Alexander Schneider; Eric Fh van Bommel; Caroline Sophie Verbeke; Marie Pierre Vullierme; Heiko Witt Journal: United European Gastroenterol J Date: 2020-06-18 Impact factor: 4.623
Authors: Jiachen Liu; Wei Yin; Lisa S Westerberg; Pamela Lee; Quan Gong; Yan Chen; Lingli Dong; Chaohong Liu Journal: Front Immunol Date: 2021-09-01 Impact factor: 7.561