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Literature DB >> 26552985

C5A Protects Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge.

Ronald S Veazey¹, Udayan Chatterji², Michael Bobardt², Kasi E Russell-Lodrigue¹, Jian Li³, Xiaolei Wang¹, Philippe A Gallay⁴.

Abstract

A safe and effective vaginal microbicide could decrease human immunodeficiency virus (HIV) transmission in women. Here, we evaluated the safety and microbicidal efficacy of a short amphipathic peptide, C5A, in a rhesus macaque model. We found that a vaginal application of C5A protects 89% of the macaques from a simian-human immunodeficiency virus (SHIV-162P3) challenge. We observed no signs of lesions or inflammation in animals vaginally treated with repeated C5A applications. With its noncellular cytotoxic activity and rare mechanism of action, C5A represents an attractive microbicidal candidate.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2015 PMID： 26552985 PMCID： PMC4704173 DOI： 10.1128/AAC.01925-15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

23 in total

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Authors: Jim A Turpin
Journal: Expert Opin Investig Drugs Date: 2002-08 Impact factor: 6.206

2. Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.

Authors: R Karl Malcolm; Deborah Lowry; Peter Boyd; Leslie Geer; Ronald S Veazey; Laurie Goldman; P J Klasse; Robin J Shattock; John P Moore
Journal: J Antimicrob Chemother Date: 2013-12-30 Impact factor: 5.790

3. Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.

Authors: R Karl Malcolm; Claire J Forbes; Leslie Geer; Ronald S Veazey; Laurie Goldman; Per Johan Klasse; John P Moore
Journal: J Antimicrob Chemother Date: 2012-10-30 Impact factor: 5.790

4. Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices.

Authors: Simi Gunaseelan; Philippe A Gallay; Michael D Bobardt; Charlene S Dezzutti; Timothy Esch; Richard Maskiewicz
Journal: Pharm Res Date: 2012-06-27 Impact factor: 4.200

5. Sublimable C5A delivery provides sustained and prolonged anti-HIV microbicidal activities.

Authors: Richard Maskiewicz; Michael Bobardt; Udayan Chatterji; Simi Gunaseelan; Charlene S Dezzutti; Francois Penin; Philippe A Gallay
Journal: Antimicrob Agents Chemother Date: 2012-03-19 Impact factor: 5.191

6. An intravaginal ring for the sustained delivery of antibodies.

Authors: Manjula Gunawardana; Marc M Baum; Thomas J Smith; John A Moss
Journal: J Pharm Sci Date: 2014-09-17 Impact factor: 3.534

7. Pharmacokinetics and preliminary safety study of pod-intravaginal rings delivering antiretroviral combinations for HIV prophylaxis in a macaque model.

Authors: John A Moss; Priya Srinivasan; Thomas J Smith; Irina Butkyavichene; Gilbert Lopez; Amanda A Brooks; Amy Martin; Chuong T Dinh; James M Smith; Marc M Baum
Journal: Antimicrob Agents Chemother Date: 2014-06-16 Impact factor: 5.191

8. Optimization of PCR for quantification of simian immunodeficiency virus genomic RNA in plasma of rhesus macaques (Macaca mulatta) using armored RNA.

Authors: C J Monjure; C D Tatum; A T Panganiban; M Arainga; V Traina-Dorge; P A Marx; E S Didier
Journal: J Med Primatol Date: 2013-11-22 Impact factor: 0.667

9. An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A.

Authors: Volker Brass; Elke Bieck; Roland Montserret; Benno Wölk; Jan Albert Hellings; Hubert E Blum; François Penin; Darius Moradpour
Journal: J Biol Chem Date: 2001-12-14 Impact factor: 5.157