Literature DB >> 26552984

fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin.

Karla de Oliveira Pelegrino1, Juliana Coutinho Campos2, Suely Carlos Ferreira Sampaio3, Karina Lezirovitz4, Bruna Mara Seco2, Mayne de Oliveira Pereira2, Darlan Augusto da Costa Rocha2, Thomas Jové5, Antonio Carlos Nicodemo1, Jorge Luiz Mello Sampaio6.   

Abstract

In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 μg/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 μg/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26552984      PMCID： PMC4704179          DOI： 10.1128/AAC.02437-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

1.  Broad-host-range plasmids from agricultural soils have IncP-1 backbones with diverse accessory genes.

Authors:  Diya Sen; Geraldine A Van der Auwera; Linda M Rogers; Christopher M Thomas; Celeste J Brown; Eva M Top
Journal:  Appl Environ Microbiol       Date:  2011-09-23       Impact factor: 4.792

2.  Novel integron-mediated fosfomycin resistance gene fosK.

Authors:  Hiromitsu Kitanaka; Jun-ichi Wachino; Wanchun Jin; Satoru Yokoyama; Masa-Aki Sasano; Mitsuhiro Hori; Keiko Yamada; Kouji Kimura; Yoshichika Arakawa
Journal:  Antimicrob Agents Chemother       Date:  2014-05-19       Impact factor: 5.191

3.  Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosis.

Authors:  Koen A L De Smet; Karen E Kempsell; Alex Gallagher; Ken Duncan; Douglas B Young
Journal:  Microbiology (Reading)       Date:  1999-11       Impact factor: 2.777

4.  Characterization of fosA5, a new plasmid-mediated fosfomycin resistance gene in Escherichia coli.

Authors:  Y Ma; X Xu; Q Guo; P Wang; W Wang; M Wang
Journal:  Lett Appl Microbiol       Date:  2014-12-21       Impact factor: 2.858

5.  Antimicrobial Activity of Fosfomycin-Tobramycin Combination against Pseudomonas aeruginosa Isolates Assessed by Time-Kill Assays and Mutant Prevention Concentrations.

Authors:  María Díez-Aguilar; María Isabel Morosini; Ana P Tedim; Irene Rodríguez; Zerrin Aktaş; Rafael Cantón
Journal:  Antimicrob Agents Chemother       Date:  2015-07-20       Impact factor: 5.191

6.  Treatment and clinical outcomes of urinary tract infections caused by KPC-producing Enterobacteriaceae in a retrospective cohort.

Authors:  Bryan T Alexander; Jonas Marschall; Robert J Tibbetts; Elizabeth A Neuner; W Michael Dunne; David J Ritchie
Journal:  Clin Ther       Date:  2012-06       Impact factor: 3.393

7.  Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways.

Authors:  N Trefault; R De la Iglesia; A M Molina; M Manzano; T Ledger; D Pérez-Pantoja; M A Sánchez; M Stuardo; B González
Journal:  Environ Microbiol       Date:  2004-07       Impact factor: 5.491

8.  The mechanism of action of fosfomycin (phosphonomycin).

Authors:  F M Kahan; J S Kahan; P J Cassidy; H Kropp
Journal:  Ann N Y Acad Sci       Date:  1974-05-10       Impact factor: 5.691

9.  Outcomes of critically ill intensive care unit patients treated with fosfomycin for infections due to pandrug-resistant and extensively drug-resistant carbapenemase-producing Gram-negative bacteria.

Authors:  Konstantinos Pontikis; Ilias Karaiskos; Styliani Bastani; George Dimopoulos; Michalis Kalogirou; Maria Katsiari; Angelos Oikonomou; Garyphallia Poulakou; Emmanuel Roilides; Helen Giamarellou
Journal:  Int J Antimicrob Agents       Date:  2013-10-16       Impact factor: 5.283

10.  The detection and sequencing of a broad-host-range conjugative IncP-1β plasmid in an epidemic strain of Mycobacterium abscessus subsp. bolletii.

Authors:  Sylvia Cardoso Leão; Cristianne Kayoko Matsumoto; Adriana Carneiro; Rommel Thiago Ramos; Christiane Lourenço Nogueira; James Daltro Lima; Karla Valéria Lima; Maria Luiza Lopes; Horacio Schneider; Vasco Ariston Azevedo; Artur da Costa da Silva
Journal:  PLoS One       Date:  2013-04-02       Impact factor: 3.240
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