Maria Granfors1, Hanna Augustin1, Johnny Ludvigsson2, Hilde K Brekke3,4. 1. Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. 2. Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. 3. Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden. hilde.brekke@nutrition.gu.se. 4. Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. hilde.brekke@nutrition.gu.se.
Abstract
BACKGROUND: Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child. METHODS: This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age. The questions 'during pregnancy, did you take any vitamin/mineral supplements?' and 'if yes, which? (open answer)' in addition to other lifestyle questions were answered. Logistic regression was performed with onset of type 1 diabetes as the dependent variable and vitamin D supplementation use as the independent variable, adjusted for relevant factors. RESULTS: Vitamin D supplementation during pregnancy was consumed by 9.3% of mothers whose children later got type1 diabetes and among 11.3% of those mothers whose children did not get type 1 diabetes (p = 0.532). No significant association was found between reported supplement intake of vitamin D during pregnancy and risk of type 1 diabetes, even when adjusting for factors which could influence the association. CONCLUSION: Maternal use of vitamin D-containing multivitamin supplements during pregnancy was not related to the risk of developing type 1 diabetes in children before 14-16 yr of age in Southeast of Sweden.
BACKGROUND: Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child. METHODS: This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age. The questions 'during pregnancy, did you take any vitamin/mineral supplements?' and 'if yes, which? (open answer)' in addition to other lifestyle questions were answered. Logistic regression was performed with onset of type 1 diabetes as the dependent variable and vitamin D supplementation use as the independent variable, adjusted for relevant factors. RESULTS:Vitamin D supplementation during pregnancy was consumed by 9.3% of mothers whose children later got type1 diabetes and among 11.3% of those mothers whose children did not get type 1 diabetes (p = 0.532). No significant association was found between reported supplement intake of vitamin D during pregnancy and risk of type 1 diabetes, even when adjusting for factors which could influence the association. CONCLUSION: Maternal use of vitamin D-containing multivitamin supplements during pregnancy was not related to the risk of developing type 1 diabetes in children before 14-16 yr of age in Southeast of Sweden.
Authors: Steffen U Thorsen; Karl Mårild; Sjurdur F Olsen; Klaus K Holst; German Tapia; Charlotta Granström; Thorhallur I Halldorsson; Arieh S Cohen; Margaretha Haugen; Marika Lundqvist; Torild Skrivarhaug; Pål R Njølstad; Geir Joner; Per Magnus; Ketil Størdal; Jannet Svensson; Lars C Stene Journal: Am J Epidemiol Date: 2018-06-01 Impact factor: 4.897
Authors: Ramune Jacobsen; Steffen U Thorsen; Arieh S Cohen; Marika Lundqvist; Peder Frederiksen; Christian B Pipper; Flemming Pociot; Lau C Thygesen; Alberto Ascherio; Jannet Svensson; Berit L Heitmann Journal: Diabetologia Date: 2016-05-30 Impact factor: 10.122
Authors: Marco Infante; Camillo Ricordi; Janine Sanchez; Michael J Clare-Salzler; Nathalia Padilla; Virginia Fuenmayor; Carmen Chavez; Ana Alvarez; David Baidal; Rodolfo Alejandro; Massimiliano Caprio; Andrea Fabbri Journal: Nutrients Date: 2019-09-11 Impact factor: 5.717
Authors: Elizabeth A DeVilbiss; Cecilia Magnusson; Renee M Gardner; Dheeraj Rai; Craig J Newschaffer; Kristen Lyall; Christina Dalman; Brian K Lee Journal: BMJ Date: 2017-10-04