Nisha S Wadhwani1, Vidya V Patil1, Savita S Mehendale2, Girija N Wagh2, Sanjay A Gupte3, Sadhana R Joshi1. 1. a Department of Nutritional Medicine, Interactive Research School for Health Affairs , Bharati Vidyapeeth University , Pune , India . 2. b Department of Obstetrics and Gynaecology , Bharati Medical College and Hospital, Bharati Vidyapeeth University , Pune , India , and. 3. c Gupte Hospital and Research Centre , Pune , India.
Abstract
OBJECTIVE: The present prospective study examines the levels of maternal plasma folate, vitamin B12 and homocysteine in normotensive control (NC) women and women with preeclampsia (PE) from early pregnancy till delivery. METHODS: The present study includes 126 NC and 62 PE women. Maternal blood was collected at 3 time points during pregnancy (T1 = 16th-20th weeks, T2 = 26th-30th weeks and T3 = at delivery). Levels of folate, vitamin B12 and homocysteine were estimated by the chemiluminescent microparticle immunoassay technology. RESULTS: Maternal plasma folate levels were similar between NC and PE women at all the time points across gestation. Maternal plasma vitamin B12 levels were significantly higher in PE (p < 0.05) as compared with NC at T2. Maternal plasma homocysteine levels were higher in PE as compared with NC at all the time points, i.e. T1, T2 (p < 0.05 for both) and T3 (p < 0.01). CONCLUSION: Our results indicate that higher homocysteine levels exist in women with PE from early pregnancy and continue till delivery.
OBJECTIVE: The present prospective study examines the levels of maternal plasma folate, vitamin B12 and homocysteine in normotensive control (NC) women and women with preeclampsia (PE) from early pregnancy till delivery. METHODS: The present study includes 126 NC and 62 PE women. Maternal blood was collected at 3 time points during pregnancy (T1 = 16th-20th weeks, T2 = 26th-30th weeks and T3 = at delivery). Levels of folate, vitamin B12 and homocysteine were estimated by the chemiluminescent microparticle immunoassay technology. RESULTS: Maternal plasma folate levels were similar between NC and PE women at all the time points across gestation. Maternal plasma vitamin B12 levels were significantly higher in PE (p < 0.05) as compared with NC at T2. Maternal plasma homocysteine levels were higher in PE as compared with NC at all the time points, i.e. T1, T2 (p < 0.05 for both) and T3 (p < 0.01). CONCLUSION: Our results indicate that higher homocysteine levels exist in women with PE from early pregnancy and continue till delivery.
Authors: Tormod Rogne; Myrte J Tielemans; Mary Foong-Fong Chong; Chittaranjan S Yajnik; Ghattu V Krishnaveni; Lucilla Poston; Vincent W V Jaddoe; Eric A P Steegers; Suyog Joshi; Yap-Seng Chong; Keith M Godfrey; Fabian Yap; Raquel Yahyaoui; Tinku Thomas; Gry Hay; Marije Hogeveen; Ahmet Demir; Ponnusamy Saravanan; Eva Skovlund; Marit P Martinussen; Geir W Jacobsen; Oscar H Franco; Michael B Bracken; Kari R Risnes Journal: Am J Epidemiol Date: 2017-02-01 Impact factor: 4.897
Authors: Nisha S Wadhwani; Deepali P Sundrani; Girija N Wagh; Savita S Mehendale; Manish M Tipnis; Priscilla C Joshi; Arun S Kinare; Sanjay K Lalwani; Narayanan S Mani; Nomita Chandhiok; Giriraj R Chandak; Sanjay A Gupte; Caroline H D Fall; Sadhana R Joshi Journal: BMC Pregnancy Childbirth Date: 2019-08-23 Impact factor: 3.007
Authors: Doris González-Fernández; Emérita Del Carmen Pons; Delfina Rueda; Odalis Teresa Sinisterra; Enrique Murillo; Marilyn E Scott; Kristine G Koski Journal: Front Public Health Date: 2020-03-24