Literature DB >> 26552067

Glyoxalase biochemistry.

John F Honek.   

Abstract

The glyoxalase enzyme system utilizes intracellular thiols such as glutathione to convert α-ketoaldehydes, such as methylglyoxal, into D-hydroxyacids. This overview discusses several main aspects of the glyoxalase system and its likely function in the cell. The control of methylglyoxal levels in the cell is an important biochemical imperative and high levels have been associated with major medical symptoms that relate to this metabolite's capability to covalently modify proteins, lipids and nucleic acid.

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Year:  2015        PMID： 26552067     DOI： 10.1515/bmc-2015-0025

Source DB:  PubMed          Journal:  Biomol Concepts        ISSN： 1868-5021


  8 in total

Review 1.  Metabolic Shades of S-D-Lactoylglutathione.

Authors:  Miklós Péter Kalapos; Cinzia Antognelli; Lidia de Bari
Journal:  Antioxidants (Basel)       Date:  2022-05-20

2.  Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells.

Authors:  Betina Schmidt; Christian Ferreira; Carlos Luan Alves Passos; Jerson Lima Silva; Eliane Fialho
Journal:  Int J Mol Sci       Date:  2020-07-24       Impact factor: 5.923

Review 3.  Carbonyl Stress in Red Blood Cells and Hemoglobin.

Authors:  Olga V Kosmachevskaya; Natalia N Novikova; Alexey F Topunov
Journal:  Antioxidants (Basel)       Date:  2021-02-07

Review 4.  Mitochondrial metabolic determinants of multiple myeloma growth, survival, and therapy efficacy.

Authors:  Remya Nair; Pulkit Gupta; Mala Shanmugam
Journal:  Front Oncol       Date:  2022-09-16       Impact factor: 5.738

5.  Hemolytic and antimalarial effects of tight-binding glyoxalase 1 inhibitors on the host-parasite unit of erythrocytes infected with Plasmodium falciparum.

Authors:  Cletus A Wezena; Miriam Urscher; Robert Vince; Swati S More; Marcel Deponte
Journal:  Redox Biol       Date:  2016-03-02       Impact factor: 11.799

6.  Discovery of GLO1 New Related Genes and Pathways by RNA-Seq on A2E-Stressed Retinal Epithelial Cells Could Improve Knowledge on Retinitis Pigmentosa.

Authors:  Luigi Donato; Concetta Scimone; Simona Alibrandi; Giacomo Nicocia; Carmela Rinaldi; Antonina Sidoti; Rosalia D'Angelo
Journal:  Antioxidants (Basel)       Date:  2020-05-13

7.  Circulating free methylglyoxal as a metabolic tumor biomarker in a rat colon adenocarcinoma model.

Authors:  Philippe Irigaray; Dominique Belpomme
Journal:  Mol Clin Oncol       Date:  2020-02-19

Review 8.  Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System.

Authors:  Patrizia Hrelia; Giulia Sita; Marina Ziche; Emma Ristori; Angela Marino; Marika Cordaro; Raffaella Molteni; Vittoria Spero; Marco Malaguti; Fabiana Morroni; Silvana Hrelia
Journal:  Oxid Med Cell Longev       Date:  2020-08-01       Impact factor: 6.543
  8 in total

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