Literature DB >> 26551692

Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.

Ryan J Middleton1, Guo-Jun Liu2, Richard B Banati2.   

Abstract

The highly conserved 18-kDa translocator protein (TSPO) or peripheral benzodiazepine receptor (PBR), is being investigated as a diagnostic and therapeutic target for disease conditions ranging from inflammation to neurodegeneration and behavioural illnesses. Many functions have been attributed to TSPO/PBR including a role in the mitochondrial permeability transition pore (MPTP), steroidogenesis and energy metabolism. In this review, we detail the recent developments in determining the physiological role of TSPO/PBR, specifically based on data obtained from the recently generated Tspo knockout mouse models. In addition to defining the role of TSPO/PBR, we also describe the value of Tspo knockout mice in determining the selectivity, specificity and presence of any off-target effects of TSPO/PBR ligands.
© 2015 Authors; published by Portland Press Limited.

Entities:  

Keywords:  TSPO/PBR; compound development; energy; knockout; metabolism; mitochondria

Mesh：

Substances：

Year:  2015        PMID： 26551692     DOI： 10.1042/BST20150039

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN： 0300-5127            Impact factor:   5.407


  7 in total

Review 1.  TSPO protein binding partners in bacteria, animals, and plants.

Authors:  Carrie Hiser; Beronda L Montgomery; Shelagh Ferguson-Miller
Journal:  J Bioenerg Biomembr       Date:  2021-06-30       Impact factor: 2.945

2.  Global Deletion of TSPO Does Not Affect the Viability and Gene Expression Profile.

Authors:  Huaishan Wang; Kangle Zhai; Yingchao Xue; Jia Yang; Qi Yang; Yi Fu; Yu Hu; Fang Liu; Weiqing Wang; Lianxian Cui; Hui Chen; Jianmin Zhang; Wei He
Journal:  PLoS One       Date:  2016-12-01       Impact factor: 3.240

3.  Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling.

Authors:  Nasra Yasin; Leo Veenman; Sukhdev Singh; Maya Azrad; Julia Bode; Alex Vainshtein; Beatriz Caballero; Ilan Marek; Moshe Gavish
Journal:  Int J Mol Sci       Date:  2017-04-07       Impact factor: 5.923

4.  Functional gains in energy and cell metabolism after TSPO gene insertion.

Authors:  Guo-Jun Liu; Ryan J Middleton; Winnie Wai-Ying Kam; David Y Chin; Claire R Hatty; Ronald H Y Chan; Richard B Banati
Journal:  Cell Cycle       Date:  2017-01-19       Impact factor: 4.534

Review 5.  The Translocator Protein (TSPO) in Mitochondrial Bioenergetics and Immune Processes.

Authors:  Calina Betlazar; Ryan J Middleton; Richard Banati; Guo-Jun Liu
Journal:  Cells       Date:  2020-02-24       Impact factor: 6.600

6.  Resolving the cellular specificity of TSPO imaging in a rat model of peripherally-induced neuroinflammation.

Authors:  Marta Vicente-Rodríguez; Nisha Singh; Federico Turkheimer; Alba Peris-Yague; Karen Randall; Mattia Veronese; Camilla Simmons; Abdul Karim Haji-Dheere; Jayanta Bordoloi; Kerstin Sander; Ramla O Awais; Erik Årstad; Diana Cash; Christine A Parker
Journal:  Brain Behav Immun       Date:  2021-05-27       Impact factor: 7.217

Review 7.  The impact of high and low dose ionising radiation on the central nervous system.

Authors:  Calina Betlazar; Ryan J Middleton; Richard B Banati; Guo-Jun Liu
Journal:  Redox Biol       Date:  2016-08-10       Impact factor: 11.799
  7 in total

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