Literature DB >> 26551546

Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.

Marc Aurel Busche1,2,3, Christine Grienberger1,4, Aylin D Keskin1, Beomjong Song1, Ulf Neumann5, Matthias Staufenbiel6, Hans Förstl2, Arthur Konnerth1,3.   

Abstract

Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.

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Year:  2015        PMID： 26551546     DOI： 10.1038/nn.4163

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  32 in total

1.  Cerebral hemorrhage after passive anti-Abeta immunotherapy.

Authors:  M Pfeifer; S Boncristiano; L Bondolfi; A Stalder; T Deller; M Staufenbiel; P M Mathews; M Jucker
Journal:  Science       Date:  2002-11-15       Impact factor: 47.728

2.  Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

Authors:  Frédérique Bard; Robin Barbour; Catherine Cannon; Robert Carretto; Michael Fox; Dora Games; Teresa Guido; Kathleen Hoenow; Kang Hu; Kelly Johnson-Wood; Karen Khan; Dora Kholodenko; Celeste Lee; Mike Lee; Ruth Motter; Minh Nguyen; Amanda Reed; Dale Schenk; Pearl Tang; Nicki Vasquez; Peter Seubert; Ted Yednock
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-03       Impact factor: 11.205

3.  Seizures and epileptiform activity in the early stages of Alzheimer disease.

Authors:  Keith A Vossel; Alexander J Beagle; Gil D Rabinovici; Huidy Shu; Suzee E Lee; Georges Naasan; Manu Hegde; Susannah B Cornes; Maya L Henry; Alexandra B Nelson; William W Seeley; Michael D Geschwind; Maria L Gorno-Tempini; Tina Shih; Heidi E Kirsch; Paul A Garcia; Bruce L Miller; Lennart Mucke
Journal:  JAMA Neurol       Date:  2013-09-01       Impact factor: 18.302

4.  Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.

Authors:  K Johnson-Wood; M Lee; R Motter; K Hu; G Gordon; R Barbour; K Khan; M Gordon; H Tan; D Games; I Lieberburg; D Schenk; P Seubert; L McConlogue
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

Review 5.  The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

Authors:  Eric Karran; Marc Mercken; Bart De Strooper
Journal:  Nat Rev Drug Discov       Date:  2011-08-19       Impact factor: 84.694

Review 6.  The evolution of preclinical Alzheimer's disease: implications for prevention trials.

Authors:  Reisa Sperling; Elizabeth Mormino; Keith Johnson
Journal:  Neuron       Date:  2014-11-05       Impact factor: 17.173

7.  Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.

Authors:  K Hsiao; P Chapman; S Nilsen; C Eckman; Y Harigaya; S Younkin; F Yang; G Cole
Journal:  Science       Date:  1996-10-04       Impact factor: 47.728

8.  Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Authors:  Jorge J Palop; Jeannie Chin; Erik D Roberson; Jun Wang; Myo T Thwin; Nga Bien-Ly; Jong Yoo; Kaitlyn O Ho; Gui-Qiu Yu; Anatol Kreitzer; Steven Finkbeiner; Jeffrey L Noebels; Lennart Mucke
Journal:  Neuron       Date:  2007-09-06       Impact factor: 17.173

9.  Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.

Authors:  D Games; D Adams; R Alessandrini; R Barbour; P Berthelette; C Blackwell; T Carr; J Clemens; T Donaldson; F Gillespie
Journal:  Nature       Date:  1995-02-09       Impact factor: 49.962

10.  Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease.

Authors:  Christine Grienberger; Nathalie L Rochefort; Helmuth Adelsberger; Horst A Henning; Daniel N Hill; Julia Reichwald; Matthias Staufenbiel; Arthur Konnerth
Journal:  Nat Commun       Date:  2012-04-10       Impact factor: 14.919
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  49 in total

1.  Alzheimer disease. Could anti-amyloid-β immunotherapy do more harm than good?

Authors:  Heather Wood
Journal:  Nat Rev Neurol       Date:  2015-11-27       Impact factor: 42.937

Review 2.  Clinical Research on Alzheimer's Disease: Progress and Perspectives.

Authors:  Bin-Lu Sun; Wei-Wei Li; Chi Zhu; Wang-Sheng Jin; Fan Zeng; Yu-Hui Liu; Xian-Le Bu; Jie Zhu; Xiu-Qing Yao; Yan-Jiang Wang
Journal:  Neurosci Bull       Date:  2018-06-28       Impact factor: 5.203

3.  BACE inhibition-dependent repair of Alzheimer's pathophysiology.

Authors:  Aylin D Keskin; Maja Kekuš; Helmuth Adelsberger; Ulf Neumann; Derya R Shimshek; Beomjong Song; Benedikt Zott; Tingying Peng; Hans Förstl; Matthias Staufenbiel; Israel Nelken; Bert Sakmann; Arthur Konnerth; Marc Aurel Busche
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-24       Impact factor: 11.205

Review 4.  Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids.

Authors:  Milan Fiala; Gijs Kooij; Karen Wagner; Bruce Hammock; Matteo Pellegrini
Journal:  FASEB J       Date:  2017-04-18       Impact factor: 5.191

Review 5.  Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.

Authors:  Jianping Guo; Ji Cheng; Brian J North; Wenyi Wei
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-07-08       Impact factor: 10.680

6.  Parvalbumin-Positive Neuron Loss and Amyloid-β Deposits in the Frontal Cortex of Alzheimer's Disease-Related Mice.

Authors:  Farhan Ali; Stephanie L Baringer; Arianna Neal; Esther Y Choi; Alex C Kwan
Journal:  J Alzheimers Dis       Date:  2019       Impact factor: 4.472

Review 7.  What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Authors:  Benedikt Zott; Marc Aurel Busche; Reisa A Sperling; Arthur Konnerth
Journal:  Annu Rev Neurosci       Date:  2018-07-08       Impact factor: 12.449

8.  A vicious cycle of β amyloid-dependent neuronal hyperactivation.

Authors:  Benedikt Zott; Manuel M Simon; Wei Hong; Felix Unger; Hsing-Jung Chen-Engerer; Matthew P Frosch; Bert Sakmann; Dominic M Walsh; Arthur Konnerth
Journal:  Science       Date:  2019-08-09       Impact factor: 47.728

Review 9.  Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease.

Authors:  S Hunter; C Brayne
Journal:  Mol Psychiatry       Date:  2017-11-07       Impact factor: 15.992

Review 10.  Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy.

Authors:  Michael Nehls
Journal:  J Mol Psychiatry       Date:  2016-07-15
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