Literature DB >> 26551334

NIR-Laser-Switched In Vivo Smart Nanocapsules for Synergic Photothermal and Chemotherapy of Tumors.

Zhouqi Meng1, Fang Wei2, Ronghua Wang2, Mengge Xia1, Zhigang Chen1, Huiping Wang2, Meifang Zhu1.   

Abstract

In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  NIR lasers; chemotherapy; photothermal therapy; smart nanocapsules; switches; tumors

Mesh:

Substances:

Year:  2015        PMID: 26551334     DOI: 10.1002/adma.201502669

Source DB:  PubMed          Journal:  Adv Mater        ISSN: 0935-9648            Impact factor:   30.849


  25 in total

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