| Literature DB >> 26551334 |
Zhouqi Meng1, Fang Wei2, Ronghua Wang2, Mengge Xia1, Zhigang Chen1, Huiping Wang2, Meifang Zhu1.
Abstract
In vivo MEO2 MA@MEO2 MA-co-OEGMA-CuS-DOX (G-CuS-DOX) nanocapsules increase the temperature of tumors from room temperature to 57 °C due to the photothermal effect under irradiation from a 915-nm laser. When the temperature exceeds 42 °C, photothermal therapy of G-CuS-DOX is switched on. Simultaneously, higher temperatures (>LCST, 42 °C) induce volume shrinkage of G-CuS-DOX in vivo, leading to the controllable release of the anticancer drug DOX. If the NIR laser is switched off, both therapy effects are interrupted immediately.Entities:
Keywords: NIR lasers; chemotherapy; photothermal therapy; smart nanocapsules; switches; tumors
Mesh:
Substances:
Year: 2015 PMID: 26551334 DOI: 10.1002/adma.201502669
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849