| Literature DB >> 26550933 |
James C Lamb1, Paolo Boffetta2, Warren G Foster3, Julie E Goodman4, Karyn L Hentz5, Lorenz R Rhomberg6, Jane Staveley7, Gerard Swaen8, Glen Van Der Kraak9, Amy L Williams10.
Abstract
Recently Bergman et al. (2015) took issue with our comments (Lamb et al., 2014) on the WHO-UNEP(1) report entitled the "State of the Science of Endocrine Disrupting Chemicals - 2012" (WHO 2013a). We find several key differences between their view and ours regarding the selection of studies and presentation of data related to endocrine disrupting chemicals (EDCs) under the WHO-IPCS(2) definition (2002). In this response we address the factors that we think are most important: 1. the difference between hazard and risk; 2. the different approaches for hazard identification (weight of the evidence [WOE] vs. emphasizing positive findings over null results); and 3. the lack of a justification for conceptual or practical differences between EDCs and other groups of agents.Keywords: Endocrine disrupting chemicals (EDC); Endocrine mode-of-action; Hazard assessment; Risk characterization; Weight of evidence
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Year: 2015 PMID: 26550933 DOI: 10.1016/j.yrtph.2015.10.029
Source DB: PubMed Journal: Regul Toxicol Pharmacol ISSN: 0273-2300 Impact factor: 3.271