Literature DB >> 26550440

Ginsenoside Rd mitigates myocardial ischemia-reperfusion injury via Nrf2/HO-1 signaling pathway.

Xiaofeng Zeng1, Juan Li2, Zhen Li1.   

Abstract

Ginsenoside Rd (GsRd) reportedly protects the heart against ischemia-reperfusion (I/R) injury. Nrf2/HO-1 signaling plays a key role in attenuating oxidative stress. However, it remains unclear whether GsRd protects against myocardial I/R injury via Nrf2/HO-1 signaling. This study aimed to investigate the role of Nrf2/HO-1 signaling in the cardioprotective effect of GsRd. Rats received 30 min ischemia followed by 2 h reperfusion. Cardiac function, infarct size and serum CK, LDH, cTnI levels were detected. The expression of Nrf2 and HO-1 was detected by western blot. The results suggested that GsRd attenuated myocardial I/R injury as evidenced by improved cardiac function, decreased infarct size and decreased levels of serum CK, LDH and cTnI. In addition, GsRd administration enhanced the expression of Nrf2 and HO-1. In conclusion, the present study shows that GsRd protects against myocardial I/R injury via Nrf2/HO-1 signaling.

Entities:  

Keywords:  Ginsenoside Rd; Nrf2/HO-1; myocardial ischemia-reperfusion injury

Year:  2015        PMID： 26550440      PMCID： PMC4613125     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  32 in total

1.  Ginsenoside-Rd from panax notoginseng blocks Ca2+ influx through receptor- and store-operated Ca2+ channels in vascular smooth muscle cells.

Authors:  Yong-Yuan Guan; Jia-Guo Zhou; Zheng Zhang; Guan-Lei Wang; Bing-Xiang Cai; Liang Hong; Qin-Ying Qiu; Hua He
Journal:  Eur J Pharmacol       Date:  2006-08-17       Impact factor: 4.432

2.  Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents.

Authors:  Dong Sun; Bing Wang; Ming Shi; Yun-Xia Zhang; Lin-Fu Zhou; Zhi-Rong Liu; Zhong-Liang Wu; Wen Jiang; Jun-Liang Han; Li-Ze Xiong; Gang Zhao
Journal:  Phytomedicine       Date:  2011-09-06       Impact factor: 5.340

3.  Ginsenoside Rd attenuates tau protein phosphorylation via the PI3K/AKT/GSK-3β pathway after transient forebrain ischemia.

Authors:  Xiao Zhang; Ming Shi; Ruidong Ye; Wei Wang; Xuedong Liu; Guangyun Zhang; Junliang Han; Yunxia Zhang; Bing Wang; Jun Zhao; Juan Hui; Lize Xiong; Gang Zhao
Journal:  Neurochem Res       Date:  2014-05-03       Impact factor: 3.996

4.  Ginsenoside Rd ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice.

Authors:  Dongliang Zhu; Mei Liu; Yaowu Yang; Lili Ma; Ying Jiang; Linli Zhou; Qiling Huang; Rongbiao Pi; Xiaohong Chen
Journal:  J Neurosci Res       Date:  2014-05-02       Impact factor: 4.164

Review 5.  Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?

Authors:  R C Siow; H Sato; G E Mann
Journal:  Cardiovasc Res       Date:  1999-02       Impact factor: 10.787

6.  Hypoxic preconditioning protects rat hearts against ischemia-reperfusion injury via the arachidonate12-lipoxygenase/transient receptor potential vanilloid 1 pathway.

Authors:  Ming-Jen Lu; Yih-Sharng Chen; Ho-Shiang Huang; Ming-Chieh Ma
Journal:  Basic Res Cardiol       Date:  2014-05-11       Impact factor: 17.165

Review 7.  Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.

Authors:  Ken Itoh; Kit I Tong; Masayuki Yamamoto
Journal:  Free Radic Biol Med       Date:  2004-05-15       Impact factor: 7.376

8.  Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons.

Authors:  Xiao-Yan Li; Jian Liang; Yong-Bo Tang; Jia-Guo Zhou; Yong-Yuan Guan
Journal:  Clin Exp Pharmacol Physiol       Date:  2009-08-28       Impact factor: 2.557

9.  Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage.

Authors:  Meihua He; Hong Pan; Raymond Chuen-Chung Chang; Kwok-Fai So; Nicholas C Brecha; Mingliang Pu
Journal:  PLoS One       Date:  2014-01-06       Impact factor: 3.240

10.  bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway.

Authors:  Zhouguang Wang; Yue Wang; Junming Ye; Xianghong Lu; Yi Cheng; Lijun Xiang; Li Chen; Wenke Feng; Hongxue Shi; Xichong Yu; Li Lin; Hongyu Zhang; Jian Xiao; Xiaokun Li
Journal:  J Cell Mol Med       Date:  2014-12-23       Impact factor: 5.310
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  14 in total

Review 1.  Nrf2 at the heart of oxidative stress and cardiac protection.

Authors:  Qin M Chen; Anthony J Maltagliati
Journal:  Physiol Genomics       Date:  2017-11-29       Impact factor: 3.107

2.  Effect of Pingchuan Guben decoction on patients with chronic obstructive pulmonary disease: Results from a randomized comparative effectiveness research trial.

Authors:  Cheng-Liang Qian; Rong Fan
Journal:  Exp Ther Med       Date:  2017-08-24       Impact factor: 2.447

3.  Oleanolic acid protects against diabetic cardiomyopathy via modulation of the nuclear factor erythroid 2 and insulin signaling pathways.

Authors:  Wei-Fang Li; Peng Wang; Hua Li; Tian-Yi Li; Ming Feng; Su-Fang Chen
Journal:  Exp Ther Med       Date:  2017-05-31       Impact factor: 2.447

4.  The Active Compounds of Yixin Ningshen Tablet and Their Potential Action Mechanism in Treating Coronary Heart Disease- A Network Pharmacology and Proteomics Approach.

Authors:  Xing Lv; Huijun Wang; Ruoming Wu; Xiaoyan Shen; Guan Ye
Journal:  Evid Based Complement Alternat Med       Date:  2020-01-25       Impact factor: 2.629

5.  Ginsenoside Rd attenuates breast cancer metastasis implicating derepressing microRNA-18a-regulated Smad2 expression.

Authors:  Peiwei Wang; Xiaoye Du; Minqi Xiong; Jingang Cui; Qinbo Yang; Wenjian Wang; Yu Chen; Teng Zhang
Journal:  Sci Rep       Date:  2016-09-19       Impact factor: 4.379

Review 6.  Functional role of ginseng-derived compounds in cancer.

Authors:  Akash Ahuja; Ji Hye Kim; Jong-Hoon Kim; Young-Su Yi; Jae Youl Cho
Journal:  J Ginseng Res       Date:  2017-05-15       Impact factor: 6.060

7.  Desflurane Preconditioning Protects Against Renal Ischemia-Reperfusion Injury and Inhibits Inflammation and Oxidative Stress in Rats Through Regulating the Nrf2-Keap1-ARE Signaling Pathway.

Authors:  Yan Zheng; Hui Lu; Huiqiong Huang
Journal:  Drug Des Devel Ther       Date:  2020-04-03       Impact factor: 4.162

Review 8.  Nrf2 for cardiac protection: pharmacological options against oxidative stress.

Authors:  Qin M Chen
Journal:  Trends Pharmacol Sci       Date:  2021-07-28       Impact factor: 17.638

9.  Yiqihuoxue decoction protects against post-myocardial infarction injury via activation of cardiomyocytes PGC-1α expression.

Authors:  Fanghe Li; Shuwen Guo; Chunguo Wang; Xiaolou Huang; Hui Wang; Xiaobo Tan; Qian Cai; Jiani Wu; Yuqin Zhang; Xi Chen; Wangou Lin; Binyue Zhang
Journal:  BMC Complement Altern Med       Date:  2018-09-17       Impact factor: 3.659

Review 10.  Pro-Resolving Effect of Ginsenosides as an Anti-Inflammatory Mechanism of Panax ginseng.

Authors:  Dong-Soon Im
Journal:  Biomolecules       Date:  2020-03-13
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