Yingdong Lian1, Zhijun Tang2, Yuxi Xie3, Zongxiang Chen1. 1. Department of Emergency, Jining First People's Hospital China. 2. Department of Orthopedics Rehabilitation and Reconstruction, Linyi People's Hospital China. 3. ICU, Hebei United University Affiliated Hospital China.
Abstract
OBJECTIVE: To assess the relationship between the polymorphisms of leptin receptor gene and hypertension. METHODS: Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein". RESULTS: Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91). CONCLUSION: Gln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertension patients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.
OBJECTIVE: To assess the relationship between the polymorphisms of leptin receptor gene and hypertension. METHODS: Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein". RESULTS: Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertensionpatients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertensionpatients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91). CONCLUSION: Gln223Arg, but not Lys109Arg gene polymorphism, is higher in hypertensionpatients, suggesting that patients with Gln223Arg allele carry a higher risk to develop hypertension.
Authors: Kazuko Masuo; Nora E Straznicky; Gavin W Lambert; Tomohiro Katsuya; Ken Sugimoto; Hiromi Rakugi; Florentia Socratous; Jacqueline Hastings; Elisabeth A Lambert; Toshio Ogihara; Murray D Esler Journal: Hypertens Res Date: 2008-06 Impact factor: 3.872
Authors: R Rosmond; Y C Chagnon; G Holm; M Chagnon; L Pérusse; K Lindell; B Carlsson; C Bouchard; P Björntorp Journal: J Clin Endocrinol Metab Date: 2000-09 Impact factor: 5.958