Zhaorong Ding1, Fang Lian2. 1. Department of Traditional Chinese Medicine, Jinan Central Hospital Affiliated to Shandong University China. 2. The Affiliated Hospital of Shandong Traditional Chinese Medical University China.
Abstract
BACKGROUND: Endometriosis is a common gynecological disease defined as the presence of endometrioid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical system, endometriosis associated infertility is mostly caused by kidney deficiency and blood stasis. The herb of reinforcing kidney and removing blood stasis is designed to treat the disease. MATERIAL AND METHODS: All the 80 up-to-standard patients were divided into two different groups exactly according to the random principle. They were treated with hormone and traditional Chinese medical herb separately. After half year's therapy, all the patients received one year's follow-up. Their transvaginal ultrasonographic changes, serum hormone levels and pregnancy rate were recorded to analysis the effect. RESULTS: No significant difference happened in two groups' demographic and clinical characteristics (P > 0.05). After the treatment, the effect on serum hormone levels and specific markers are significant (P < 0.05). The transvaginal ultrasonographic changes were positive, too. The text on hepatic and renal function confirmed to the safety of the herb. Compared to hormone therapy, the traditional Chinese medical herb is safe and effective for endometriosis patients with infertility. CONCLUSION: Compared with hormone therapy, traditional Chinese medical herb's two-staged therapy is effective and safe for endometriosis patients with infertility.
BACKGROUND:Endometriosis is a common gynecological disease defined as the presence of endometrioid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical system, endometriosis associated infertility is mostly caused by kidney deficiency and blood stasis. The herb of reinforcing kidney and removing blood stasis is designed to treat the disease. MATERIAL AND METHODS: All the 80 up-to-standard patients were divided into two different groups exactly according to the random principle. They were treated with hormone and traditional Chinese medical herb separately. After half year's therapy, all the patients received one year's follow-up. Their transvaginal ultrasonographic changes, serum hormone levels and pregnancy rate were recorded to analysis the effect. RESULTS: No significant difference happened in two groups' demographic and clinical characteristics (P > 0.05). After the treatment, the effect on serum hormone levels and specific markers are significant (P < 0.05). The transvaginal ultrasonographic changes were positive, too. The text on hepatic and renal function confirmed to the safety of the herb. Compared to hormone therapy, the traditional Chinese medical herb is safe and effective for endometriosispatients with infertility. CONCLUSION: Compared with hormone therapy, traditional Chinese medical herb's two-staged therapy is effective and safe for endometriosispatients with infertility.
Entities:
Keywords:
Endometriosis; infertility; mifepristone; traditional Chinese medicine
Authors: Wee Liak Hoo; Andreas Stavroulis; Kate Pateman; Ertan Saridogan; Alfred Cutner; George Pandis; Edward N C Tong; Davor Jurkovic Journal: Hum Reprod Date: 2014-02-02 Impact factor: 6.918