| Literature DB >> 26550208 |
Huan Bao1, Jun-Jie Hao1, Yu-Mei Yang1, Xia-Hong Xu1, Yue Wang1, Lian Zuo1, Jing Lu1, Jing Zhang1, Yue Zhang1, Si-Yi Xu1, Xuan Wang1, Ying Li1, Gang Li1.
Abstract
The angiotensinogen M235T polymorphism was associated with ischemic stroke risk. However, the results were controversial. Thus, a meta-analysis was conducted. NCBI, Medline, Web of Science and Embase databases were systematically searched. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models. There was a significant association between angiotensinogen M235T polymorphism and ischemic stroke risk (OR = 1.69; 95% CI, 1.35-2.11; P < 0.001). In the stratified analysis by ethnicity, we found that this polymorphism was significantly associated with ischemic stroke in Asian (OR = 1.85; 95% CI, 1.45-2.35; P < 0.001). In the age subgroup, we found that angiotensinogen M235T polymorphism could increase both early-onset ischemic stroke risk (OR = 1.88; 95% CI, 1.33-2.43; P < 0.001) and late-onset ischemic stroke risk (OR = 1.20; 95% CI, 1.01-1.39; P = 0.04). This meta-analysis suggested that angiotensinogen M235T polymorphism was associated with ischemic stroke.Entities:
Keywords: Ischemic stroke; angiotensinogen; genetic; meta-analysis
Year: 2015 PMID： 26550208 PMCID： PMC4612893
Source DB: PubMed Journal: Int J Clin Exp Med ISSN： 1940-5901