Literature DB >> 26550191

Bone mesenchymal stem cells overexpressing FGF4 contribute to liver regeneration in an animal model of liver cirrhosis.

Jun Wang1, Lijuan Xu2, Qianqian Chen2, Yunwei Zhang2, Yazhuo Hu3, Li Yan2.   

Abstract

It is recognized that Fibroblast Growth Factor 4 (FGF-4) could not only increase the proliferation of bone marrow mesenchymal stem cells (BMSCs), but also induce BMSCs into hepatocyte-like cells in vitro. However, the role of FGF4 played in liver regeneration in vivo is unclear. This study constructed FGF4 overexpressing BMSCs and then transplanted them into cirrhotic rats to investigate the role of FGF4 played in liver regeneration. The results showed that FGF4 promoted the location of the BMSCs only at the early stage, and more proliferating cell nuclear antigen (PCNA), epithelial cell adhesion molecule (EpCAM) and Jagged-1 positive hepatocytes were found in the cirrhotic rats. This study indicated that FGF4 transduced BMSCs contributed to liver regeneration might by the transplanted microenvironment.

Entities:  

Keywords:  BMSCs; microenvironment Introduction; migration; proliferation; transplant

Year:  2015        PMID： 26550191      PMCID： PMC4612876     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  18 in total

1.  Hepatitis B in China.

Authors:  Jie Liu; Daiming Fan
Journal:  Lancet       Date:  2007-05-12       Impact factor: 79.321

2.  FGF4 and HGF promote differentiation of mouse bone marrow mesenchymal stem cells into hepatocytes via the MAPK pathway.

Authors:  T Lu; C Yang; H Sun; J Lv; F Zhang; X J Dong
Journal:  Genet Mol Res       Date:  2014-01-21

3.  Autologous bone marrow mesenchymal stem cell transplantation in liver failure patients caused by hepatitis B: short-term and long-term outcomes.

Authors:  Liang Peng; Dong-ying Xie; Bing-Liang Lin; Jing Liu; Hai-peng Zhu; Chan Xie; Yu-bao Zheng; Zhi-liang Gao
Journal:  Hepatology       Date:  2011-07-14       Impact factor: 17.425

4.  Potential therapeutic application of intravenous autologous bone marrow infusion in patients with alcoholic liver cirrhosis.

Authors:  Takafumi Saito; Kazuo Okumoto; Hiroaki Haga; Yuko Nishise; Rika Ishii; Chikako Sato; Hisayoshi Watanabe; Akio Okada; Motoki Ikeda; Hitoshi Togashi; Tsuyoshi Ishikawa; Shuji Terai; Isao Sakaida; Sumio Kawata
Journal:  Stem Cells Dev       Date:  2011-05-11       Impact factor: 3.272

5.  Secreted factors of human liver-derived mesenchymal stem cells promote liver regeneration early after partial hepatectomy.

Authors:  Suomi M G Fouraschen; Qiuwei Pan; Petra E de Ruiter; Waqar R R Farid; Geert Kazemier; Jaap Kwekkeboom; Jan N M Ijzermans; Herold J Metselaar; Hugo W Tilanus; Jeroen de Jonge; Luc J W van der Laan
Journal:  Stem Cells Dev       Date:  2012-05-15       Impact factor: 3.272

6.  Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways.

Authors:  Seung-Cheol Choi; Su-Jin Kim; Ji-Hyun Choi; Chi-Yeon Park; Wan-Joo Shim; Do-Sun Lim
Journal:  Stem Cells Dev       Date:  2008-08       Impact factor: 3.272

7.  Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes.

Authors:  Li Yan; Ying Han; Jingbo Wang; Jingmei Liu; Liu Hong; Daiming Fan
Journal:  Am J Hematol       Date:  2007-11       Impact factor: 10.047

8.  Peripheral blood monocytes from the decompensated liver cirrhosis could migrate into nude mouse liver with human hepatocyte-markers expression.

Authors:  Li Yan; Ying Han; Jingbo Wang; Jingmei Liu; Yuanlong He; Honghong Wang; Daiming Fan
Journal:  Biochem Biophys Res Commun       Date:  2008-04-22       Impact factor: 3.575

9.  Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration.

Authors:  Yue Yu; Ai-Hua Yao; Nian Chen; Li-Yong Pu; Ye Fan; Ling Lv; Bei-Cheng Sun; Guo-Qiang Li; Xue-Hao Wang
Journal:  Mol Ther       Date:  2007-05-22       Impact factor: 11.454

10.  Differentiation and migration of bone marrow mesenchymal stem cells transplanted through the spleen in rats with portal hypertension.

Authors:  Song Sun; Gong Chen; Menghua Xu; Yingli Qiao; Shan Zheng
Journal:  PLoS One       Date:  2013-12-10       Impact factor: 3.240
View more
  4 in total

1.  Liver damage in bleomycin-induced pulmonary fibrosis in mice.

Authors:  V R Vásquez-Garzón; A Ramírez-Cosmes; E Reyes-Jiménez; G Carrasco-Torres; S Hernández-García; S R Aguilar-Ruiz; H Torres-Aguilar; J Alpuche; L Pérez-Campos Mayoral; S Pina-Canseco; J Arellanes-Robledo; S Villa-Treviño; R Baltiérrez-Hoyos
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-07-16       Impact factor: 3.000

2.  Thioredoxin-1 Protects Bone Marrow-Derived Mesenchymal Stromal Cells from Hyperoxia-Induced Injury In Vitro.

Authors:  Lei Zhang; Jin Wang; Yan Chen; Lingkong Zeng; Qiong Li; Yalan Liu; Lin Wang
Journal:  Oxid Med Cell Longev       Date:  2018-01-21       Impact factor: 6.543

Review 3.  Advance of Mesenchymal Stem Cells in Chronic End-Stage Liver Disease Control.

Authors:  Yun Gao; Xiushan Yin; Xiaomeng Ren
Journal:  Stem Cells Int       Date:  2022-10-07       Impact factor: 5.131

Review 4.  Genetic modification by overexpression of target gene in mesenchymal stromal cell for treating liver diseases.

Authors:  Chenxia Hu; Lingfei Zhao; Lanjuan Li
Journal:  J Mol Med (Berl)       Date:  2021-01-02       Impact factor: 4.599
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.