Literature DB >> 26550180

Peroxisome proliferator-activated receptor gamma (PPARG) rs1801282 C>G polymorphism is associated with cancer susceptibility in asians: an updated meta-analysis.

Yafeng Wang1, Yu Chen2, Heping Jiang3, Weifeng Tang4, Mingqiang Kang4, Tianyun Liu5, Zengqing Guo2, Zhiqiang Ma6.   

Abstract

Peroxisome proliferator-activated receptor gamma (PPARG) is related to inflammation and plays an important role in the development of cancer. PPARG rs1801282 C>G polymorphism might influence the risk of cancer by regulating production of PPARG gene. Hence, a comprehensive meta-analysis was conducted to explore the association of PPARG rs1801282 C>G polymorphism with cancer susceptibility. An extensive search of PubMed and Embase databases for all relevant publications was carried out. A total of 38 publications with 16,844 cancer cases and 23,736 controls for PPARG rs1801282 C>G polymorphism were recruited in our study. Our results indicated that PPARG rs1801282 C>G variants were associated with an increased cancer risk in Asian populations and gastric cancer. In summary, the findings suggest that PPARG rs1801282 C>G polymorphism may play a crucial role in malignant transformation and the development of cancer.

Entities:  

Keywords:  Cancer; meta-analysi; peroxisome proliferator-activated receptor gamma; polymorphism

Year:  2015        PMID： 26550180      PMCID： PMC4612865     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  52 in total

1.  Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese.

Authors:  S-Y Liao; Z-R Zeng; W K Leung; S-Z Zhou; B Chen; J J Y Sung; P-J Hu
Journal:  Aliment Pharmacol Ther       Date:  2006-01-15       Impact factor: 8.171

2.  Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes.

Authors:  Ulla Vogel; Jane Christensen; Håkan Wallin; Søren Friis; Bjørn A Nexø; Anne Tjønneland
Journal:  Mutat Res       Date:  2007-01-20       Impact factor: 2.433

3.  Lack of an association of programmed cell death-1 PD1.3 polymorphism with risk of hepatocellular carcinoma susceptibility in Turkish population: a case-control study.

Authors:  Süleyman Bayram; Hikmet Akkız; Yakup Ülger; Aynur Bekar; Ersin Akgöllü; Selçuk Yıldırım
Journal:  Gene       Date:  2012-10-04       Impact factor: 3.688

4.  No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.

Authors:  Louise E McGreavey; Faye Turner; Gillian Smith; Katherine Boylan; D Timothy Bishop; David Forman; C Roland Wolf; Jennifer H Barrett
Journal:  Pharmacogenet Genomics       Date:  2005-10       Impact factor: 2.089

5.  Lack of association of the codon 12 polymorphism of the peroxisome proliferator-activated receptor gamma gene with breast cancer and body mass.

Authors:  Asli Memisoglu; Susan E Hankinson; JoAnn E Manson; Graham A Colditz; David J Hunter
Journal:  Pharmacogenetics       Date:  2002-11

6.  Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells.

Authors:  Teturou Satoh; Mitsuo Toyoda; Hideki Hoshino; Tsuyoshi Monden; Masanobu Yamada; Hiroyuki Shimizu; Kaoru Miyamoto; Masatomo Mori; Masanabu Yamada; Matsumoto Mori
Journal:  Oncogene       Date:  2002-03-28       Impact factor: 9.867

7.  Influence of peroxisome proliferator-activated receptor (PPAR)gamma Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese.

Authors:  Tomomitsu Tahara; Tomiyasu Arisawa; Tomoyuki Shibata; Masakatsu Nakamura; Fangyu Wang; Naoko Maruyama; Yoshio Kamiya; Masahiko Nakamura; Hiroshi Fujita; Mitsuo Nagasaka; Masami Iwata; Kazuya Takahama; Makoto Watanabe; Ichiro Hirata; Hiroshi Nakano
Journal:  Dig Dis Sci       Date:  2007-09-01       Impact factor: 3.199

8.  PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).

Authors:  Martha L Slattery; Karen Curtin; Roger Wolff; Khe Ni Ma; Carol Sweeney; Maureen Murtaugh; John D Potter; Theodore R Levin; Wade Samowitz
Journal:  Cancer Causes Control       Date:  2006-04       Impact factor: 2.506

9.  Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer.

Authors:  Daniele Campa; Shanbeh Zienolddiny; Valentina Maggini; Vidar Skaug; Aage Haugen; Federico Canzian
Journal:  Carcinogenesis       Date:  2003-11-06       Impact factor: 4.944

10.  Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease.

Authors:  Lisa Gallicchio; Meghan A McSorley; Craig J Newschaffer; Han-Yao Huang; Lucy W Thuita; Sandra C Hoffman; Kathy J Helzlsouer
Journal:  Cancer Detect Prev       Date:  2007-04-10
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  7 in total

1.  PPARG c.1347C>T polymorphism is associated with cancer susceptibility: from a case-control study to a meta-analysis.

Authors:  Hao Ding; Yuanmei Chen; Hao Qiu; Chao Liu; Yafeng Wang; Mingqiang Kang; Weifeng Tang
Journal:  Oncotarget       Date:  2017-09-15

2.  The relationship between IGF2BP2 and PPARG polymorphisms and susceptibility to esophageal squamous-cell carcinomas in the eastern Chinese Han population.

Authors:  Hao Qiu; Yafeng Wang; Mingqiang Kang; Hao Ding; Chao Liu; Weifeng Tang; Zhenzhou Xiao; Yu Chen
Journal:  Onco Targets Ther       Date:  2017-11-21       Impact factor: 4.147

3.  Relationship of PPARG, PPARGC1A, and PPARGC1B polymorphisms with susceptibility to hepatocellular carcinoma in an eastern Chinese Han population.

Authors:  Sheng Zhang; Jiakai Jiang; Zhan Chen; Yafeng Wang; Weifeng Tang; Yu Chen; Longgen Liu
Journal:  Onco Targets Ther       Date:  2018-08-08       Impact factor: 4.147

4.  Non-random distribution of gastric cancer susceptible loci on human chromosomes.

Authors:  Ghazale Mahjoub; Mostafa Saadat
Journal:  EXCLI J       Date:  2018-08-17       Impact factor: 4.068

5.  Genetic polymorphisms and gastric cancer risk: a comprehensive review synopsis from meta-analysis and genome-wide association studies.

Authors:  Jie Tian; Guanchu Liu; Chunjian Zuo; Caiyang Liu; Wanlun He; Huanwen Chen
Journal:  Cancer Biol Med       Date:  2019-05       Impact factor: 5.347

6.  Peroxisome proliferator-activated receptor-γ polymorphism (rs1801282) is associated with obesity in Egyptian patients with coronary artery disease and type 2 diabetes mellitus.

Authors:  Nehal Salah Hasan; Solaf Ahmed Kamel; Mona Hamed; Eman Awadallah; Amany Hosny Abdel Rahman; Nevine Ibrahim Musa; Ghada Hussein Sayed Hussein
Journal:  J Genet Eng Biotechnol       Date:  2017-08-08

7.  Identification of Autophagy-Associated Biomarkers and Corresponding Regulatory Factors in the Progression of Colorectal Cancer.

Authors:  Chunrui Zhang; Jing Jiang; Liqiang Wang; Liyu Zheng; Jiankai Xu; Xiaolin Qi; Huiying Huang; Jianping Lu; Kongning Li; Hong Wang
Journal:  Front Genet       Date:  2020-03-18       Impact factor: 4.599
  7 in total

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