Xin-Quan Jiang1, Lei Zhang2, Hong-Ai Liu3, Ning Yuan1, Pei-Qiang Hou4, Rong-Qiang Zhang4, Tuo Wu1. 1. Institute of Public Health, Taishan Medical University No.619 Changcheng Road, Taian, Shandong, People's Republic of China. 2. Clinical Laboratory, Maternity and Child Health Care Hospital District of Dong Chang Fu, Liaocheng, Shandong, People's Republic of China. 3. Clinical Laboratory, Taishan Sanatorium Taian, Shandong, People's Republic of China. 4. Center for Disease Control and Prevention Taian, Shandong, People's Republic of China.
Abstract
OBJECTIVE: Aim to investigate the proportion of CD14(+)CD16(+) monocytes and understand the pathogenesis of this monocyte subset in acute leukemia. METHODS: Flow cytometry was utilized to study the phenotype expression of CD14(+)CD16(+) monocytes and CD3(+) T lymphocytes in peripheral blood derived from patients with acute leukemia. All the data were analyzed by SPSS 13.0 software. RESULTS: The proportion of CD14(+)CD16(+) monocytes including both intermediate and non-classical monocytes, increased significantly in patients with acute leukemia and changed negatively or positively according to the disease process. Meanwhile, the proportion of CD14(+)CD16(+) monocytes was inversely correlated with absolute number of CD4(+) T lymphocytes, ratio of CD4(+)/CD8(+) T cells, and positively correlated with the proportion of neutrophil granulocytes. CONCLUSIONS: The proportion of CD14(+)CD16(+) monocytes (especially the intermediate subpopulation) is related to the progression of acute leukemia, and the expansion of this monocyte subset could indicate the severity of the disease.
OBJECTIVE: Aim to investigate the proportion of CD14(+)CD16(+) monocytes and understand the pathogenesis of this monocyte subset in acute leukemia. METHODS: Flow cytometry was utilized to study the phenotype expression of CD14(+)CD16(+) monocytes and CD3(+) T lymphocytes in peripheral blood derived from patients with acute leukemia. All the data were analyzed by SPSS 13.0 software. RESULTS: The proportion of CD14(+)CD16(+) monocytes including both intermediate and non-classical monocytes, increased significantly in patients with acute leukemia and changed negatively or positively according to the disease process. Meanwhile, the proportion of CD14(+)CD16(+) monocytes was inversely correlated with absolute number of CD4(+) T lymphocytes, ratio of CD4(+)/CD8(+) T cells, and positively correlated with the proportion of neutrophil granulocytes. CONCLUSIONS: The proportion of CD14(+)CD16(+) monocytes (especially the intermediate subpopulation) is related to the progression of acute leukemia, and the expansion of this monocyte subset could indicate the severity of the disease.
Entities:
Keywords:
Acute leukemia; T lymphocyte; inflammation; monocyte subset
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