Weifeng Tang1, Yafeng Wang2, Yuanmei Chen3, Haiyong Gu4, Shuchen Chen1, Mingqiang Kang1. 1. Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical University Fuzhou, Fujian Province, China. 2. Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China. 3. Department of Thoracic Surgery, Fujian Provincial Cancer Hospital Fuzhou, Fujian Province, China. 4. Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
Abstract
OBJECTIVES: The correlation between intercellular adhesion molecule 1 (ICAM-1) common polymorphisms (rs5498 A>G and rs3093030 C>T) and cancer susceptibility has been explored in various ethnic groups and different cancer types; however, these investigations have yielded contradictory results. To address the relationship more precisely, we performed this meta-analysis. DESIGN AND METHODS: EmBase, PubMed and China National Knowledge Infrastructure (CNKI) databases were searched by two authors independently for eligible publications before April 8, 2015. Random-effects or fixed-effects model was harnessed to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) when appropriate. RESULTS: The result suggested that the ICAM-1 rs5498 A>G polymorphism is not associated with cancer susceptibility in overall cancer. In a stratified analysis by ethnicity, a significant increased cancer risk was identified among Asians, but the inverse association was found among Caucasians. In a stratified analysis by cancer type, ICAM-1 rs5498 A>G polymorphism was associated with a significantly increased risk of oral cancer, but with protection from colorectal cancer and melanoma. ICAM-1 rs3093030 C>T polymorphism is not correlated with cancer susceptibility. CONCLUSIONS: In summary, this meta-analysis highlights that the ICAM-1 rs5498 A>G polymorphism probably contributes to decreased susceptibility to cancer, especially in Caucasians, in melanoma and colorectal cancer subgroup, but it may be a risk factor for oral cancer and Asians.
OBJECTIVES: The correlation between intercellular adhesion molecule 1 (ICAM-1) common polymorphisms (rs5498 A>G and rs3093030 C>T) and cancer susceptibility has been explored in various ethnic groups and different cancer types; however, these investigations have yielded contradictory results. To address the relationship more precisely, we performed this meta-analysis. DESIGN AND METHODS: EmBase, PubMed and China National Knowledge Infrastructure (CNKI) databases were searched by two authors independently for eligible publications before April 8, 2015. Random-effects or fixed-effects model was harnessed to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) when appropriate. RESULTS: The result suggested that the ICAM-1rs5498 A>G polymorphism is not associated with cancer susceptibility in overall cancer. In a stratified analysis by ethnicity, a significant increased cancer risk was identified among Asians, but the inverse association was found among Caucasians. In a stratified analysis by cancer type, ICAM-1rs5498 A>G polymorphism was associated with a significantly increased risk of oral cancer, but with protection from colorectal cancer and melanoma. ICAM-1rs3093030 C>T polymorphism is not correlated with cancer susceptibility. CONCLUSIONS: In summary, this meta-analysis highlights that the ICAM-1rs5498 A>G polymorphism probably contributes to decreased susceptibility to cancer, especially in Caucasians, in melanoma and colorectal cancer subgroup, but it may be a risk factor for oral cancer and Asians.
Entities:
Keywords:
Cancer; ICAM-1; cancer susceptibility; meta-analysis; polymorphism
Authors: Ravindran Ankathil; Mohd Aminudin Mustapha; Ahmad Aizat Abdul Aziz; Siti Nurfatimah Mohd Shahpudin; Andee Dzulkarnaen Zakaria; Muhammad Radzi Abu Hassan; Kamarul Imran Musa Journal: Asian Pac J Cancer Prev Date: 2019-06-01