Shingo Maeda1, Yoshihide Takahashi2, Akihiko Nogami3, Yasuteru Yamauchi4, Yuki Osaka5, Yasuhiro Shirai1, Kensuke Ihara1, Yasuhiro Yokoyama1, Makoto Suzuki6, Kaoru Okishige7, Mitsuhiro Nishizaki8, Kenzo Hirao1. 1. Heart Rhythm Center, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. 2. Department of Cardiology, National Disaster Medical Center, Tokyo, Japan. 3. Department of Heart Rhythm Management, Yokohama Rosai Hospital, Yokohama, Japan. 4. Department of Cardiology, Musashino Red Cross Hospital, Tokyo, Japan. 5. Department of Cardiology, Yokosuka Kyosai Hospital, Yokosuka, Japan. 6. Department of Cardiovascular Medicine, Kameda General Hospital, Kamogawa, Japan. 7. Heart Center, Yokohama City Bay Red Cross Hospital, Yokohama, Japan. 8. Department of Cardiology, Yokohama Minami Kyosai Hospital, Yokohama, Japan.
Abstract
BACKGROUND: Ventricular fibrillation (VF) in Brugada syndrome (BrS) is known to occur more frequently during nighttime and from spring to early summer. In this study, we investigated whether early repolarization syndrome (ERS) has the same seasonal, weekly, and circadian distribution of VF events as BrS using data from the "J-wave associated with prior cardiac event" (J-PREVENT) registry. METHODS: The study included 90 consecutive patients with BrS and 31 patients with ERS during a mean follow-up of 49±37 months. Follow-up data from implantable cardioverter-defibrillators were evaluated in all cases. RESULTS: In patients with ERS, the circadian distribution of VF episodes differed among the four 6-h periods, with a significant peak from midnight to 6:00 am (p<0.01) similar to that observed in BrS patients. However, VF occurred more frequently on weekends in patients with ERS, whereas on weekdays in patients with BrS (p<0.01). The months of peak VF occurrence also differed between the groups, with the frequency of VF episodes at peak between December and March in ERS patients and between March and June in BrS patients. In ERS patients, VF events had an inverse correlation with air temperature (r=-0.726, p<0.01). CONCLUSIONS: ERS and BrS patients show similar nighttime increases in the occurrence of VF, but different seasonal and weekly distributions, suggesting a pathophysiological difference between the two syndromes.
BACKGROUND:Ventricular fibrillation (VF) in Brugada syndrome (BrS) is known to occur more frequently during nighttime and from spring to early summer. In this study, we investigated whether early repolarization syndrome (ERS) has the same seasonal, weekly, and circadian distribution of VF events as BrS using data from the "J-wave associated with prior cardiac event" (J-PREVENT) registry. METHODS: The study included 90 consecutive patients with BrS and 31 patients with ERS during a mean follow-up of 49±37 months. Follow-up data from implantable cardioverter-defibrillators were evaluated in all cases. RESULTS: In patients with ERS, the circadian distribution of VF episodes differed among the four 6-h periods, with a significant peak from midnight to 6:00 am (p<0.01) similar to that observed in BrS patients. However, VF occurred more frequently on weekends in patients with ERS, whereas on weekdays in patients with BrS (p<0.01). The months of peak VF occurrence also differed between the groups, with the frequency of VF episodes at peak between December and March in ERSpatients and between March and June in BrS patients. In ERSpatients, VF events had an inverse correlation with air temperature (r=-0.726, p<0.01). CONCLUSIONS:ERS and BrS patients show similar nighttime increases in the occurrence of VF, but different seasonal and weekly distributions, suggesting a pathophysiological difference between the two syndromes.
Authors: Kishlay Anand; Arash Aryana; David Cloutier; Tom Hee; Dennis Esterbrooks; Aryan N Mooss; Syed M Mohiuddin Journal: Am J Cardiol Date: 2007-07-24 Impact factor: 2.778
Authors: Seung-Young Roh; Jong-Il Choi; Min Sun Kim; Eun Young Cho; Yun Gi Kim; Kwang-No Lee; Jaemin Shim; Jin Seok Kim; Young-Hoon Kim Journal: PLoS One Date: 2020-11-25 Impact factor: 3.240