Literature DB >> 26549978

Generation 3 PAMAM dendrimer TAMRA conjugates containing precise dye/dendrimer ratios.

Janet Manono1, Casey A Dougherty2, Kirsten Jones1, Joshua DeMuth2, Mark M Banaszak Holl2, Stassi DiMaggio1.   

Abstract

The synthesis, isolation, and characterization of generation 3 poly(amidoamine) (G3 PAMAM) dendrimer containing precise ratios of 5-carboxytetramethylrhodamine succinimidyl ester (TAMRA) dye (n = 1-3) per polymer particle are reported. Stochastic conjugation of TAMRA dye to the dendrimer was followed by separation into precise dye-polymer ratios using rp-HPLC. The isolated materials were characterized by rp-UPLC, MALDI-TOF-MS, and 1H NMR spectroscopy, UV-vis, and fluorescence spectroscopies.

Entities:  

Keywords:  Fluorescent dye; PAMAM; Poly(amidoamine) dendrimer; rp-HPLC

Year:  2015        PMID： 26549978      PMCID： PMC4631223          DOI： 10.1016/j.mtcomm.2015.06.006

Source DB:  PubMed          Journal:  Mater Today (Kidlington)        ISSN： 1369-7021            Impact factor:   31.041


  21 in total

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5.  Fluorophore:dendrimer ratio impacts cellular uptake and intracellular fluorescence lifetime.

Authors:  Casey A Dougherty; Sriram Vaidyanathan; Bradford G Orr; Mark M Banaszak Holl
Journal:  Bioconjug Chem       Date:  2015-02-05       Impact factor: 4.774

6.  Isolation and characterization of precise dye/dendrimer ratios.

Authors:  Casey A Dougherty; Joseph C Furgal; Mallory A van Dongen; Theodore Goodson; Mark M Banaszak Holl; Janet Manono; Stassi DiMaggio
Journal:  Chemistry       Date:  2014-03-06       Impact factor: 5.236

7.  Quantitative analysis of generation and branch defects in G5 poly(amidoamine) dendrimer.

Authors:  Mallory A van Dongen; Ankur Desai; Bradford G Orr; James R Baker; Mark M Banaszak Holl
Journal:  Polymer (Guildf)       Date:  2013-07-19       Impact factor: 4.430

8.  Combining aminocyanine dyes with polyamide dendrons: a promising strategy for imaging in the near-infrared region.

Authors:  Cátia Ornelas; Rachelle Lodescar; Alexander Durandin; James W Canary; Ryan Pennell; Leonard F Liebes; Marcus Weck
Journal:  Chemistry       Date:  2011-02-17       Impact factor: 5.236

9.  A quantitative assessment of nanoparticle-ligand distributions: implications for targeted drug and imaging delivery in dendrimer conjugates.

Authors:  Douglas G Mullen; Ming Fang; Ankur Desai; James R Baker; Bradford G Orr; Mark M Banaszak Holl
Journal:  ACS Nano       Date:  2010-02-23       Impact factor: 15.881

10.  PAMAM structure-based multifunctional fluorescent conjugates for improved fluorescent labelling of biomacromolecules.

Authors:  C Wängler; G Moldenhauer; R Saffrich; E-M Knapp; B Beijer; M Schnölzer; B Wängler; M Eisenhut; U Haberkorn; W Mier
Journal:  Chemistry       Date:  2008       Impact factor: 5.236
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  1 in total

1.  Increase in Dye:Dendrimer Ratio Decreases Cellular Uptake of Neutral Dendrimers in RAW Cells.

Authors:  Sriram Vaidyanathan; Milan Kaushik; Casey Dougherty; Rahul Rattan; Sascha N Goonewardena; Mark M Banaszak Holl; Janet Monano; Stassi DiMaggio
Journal:  ACS Biomater Sci Eng       Date:  2016-07-18
  1 in total

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