Literature DB >> 26549884

Neuropeptide Y: An Anti-Aging Player?

Mariana Botelho1, Cláudia Cavadas2.   

Abstract

Accumulating evidence suggests that neuropeptide Y (NPY) has a role in aging and lifespan determination. In this review, we critically discuss age-related changes in NPY levels in the brain, together with recent findings concerning the contribution of NPY to, and impact on, six hallmarks of aging, specifically: loss of proteostasis, stem cell exhaustion, altered intercellular communication, deregulated nutrient sensing, cellular senescence, and mitochondrial dysfunction. Understanding how NPY contributes to, and counteracts, these hallmarks of aging will open new avenues of research on limiting damage related to aging.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  autophagy; caloric restriction; hallmarks of aging; inflammation; neuropeptide Y; senescence; stem cells

Mesh：

Substances：

Year:  2015        PMID： 26549884     DOI： 10.1016/j.tins.2015.08.012

Source DB:  PubMed          Journal:  Trends Neurosci        ISSN： 0166-2236            Impact factor:   13.837


  15 in total

Review 1.  Physiological and Therapeutic Roles of Neuropeptide Y on Biological Functions.

Authors:  Pravin Shende; Drashti Desai
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

2.  Genetic variation in glia-neuron signalling modulates ageing rate.

Authors:  Jiang-An Yin; Ge Gao; Xi-Juan Liu; Zi-Qian Hao; Kai Li; Xin-Lei Kang; Hong Li; Yuan-Hong Shan; Wen-Li Hu; Hai-Peng Li; Shi-Qing Cai
Journal:  Nature       Date:  2017-11-08       Impact factor: 49.962

3.  Interaction of neuropeptide F and diet levels effects carbonyl levels in grasshoppers.

Authors:  Matthew J Heck; John D Hatle
Journal:  Exp Gerontol       Date:  2018-10-11       Impact factor: 4.032

4.  Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer.

Authors:  Peter Dietrich; Laura Wormser; Valerie Fritz; Tatjana Seitz; Monica De Maria; Alexandra Schambony; Andreas E Kremer; Claudia Günther; Timo Itzel; Wolfgang E Thasler; Andreas Teufel; Jonel Trebicka; Arndt Hartmann; Markus F Neurath; Stephan von Hörsten; Anja K Bosserhoff; Claus Hellerbrand
Journal:  J Clin Invest       Date:  2020-05-01       Impact factor: 14.808

5.  Support cells in the brain promote longevity.

Authors:  Jason Wayne Miklas; Anne Brunet
Journal:  Science       Date:  2020-01-24       Impact factor: 47.728

Review 6.  Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging.

Authors:  Alexandra Moreira-Pais; Rita Ferreira; Paula A Oliveira; José A Duarte
Journal:  Biogerontology       Date:  2021-07-29       Impact factor: 4.277

7.  Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise.

Authors:  Vagner Ramon Rodrigues Silva; Carlos Kiyoshi Katashima; Carla G Bueno Silva; Luciene Lenhare; Thayana Oliveira Micheletti; Rafael Ludemann Camargo; Ana Carolina Ghezzi; Juliana Alves Camargo; Alexandre Moura Assis; Natalia Tobar; Joseane Morari; Daniela S Razolli; Leandro Pereira Moura; José Rodrigo Pauli; Dennys Esper Cintra; Lício Augusto Velloso; Mario J A Saad; Eduardo Rochete Ropelle
Journal:  Aging (Albany NY)       Date:  2016-12-26       Impact factor: 5.682

8.  Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.

Authors:  Anuradha Bhukel; Christine Brigitte Beuschel; Marta Maglione; Martin Lehmann; Gabor Juhász; Frank Madeo; Stephan J Sigrist
Journal:  Nat Commun       Date:  2019-03-21       Impact factor: 14.919

9.  Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation.

Authors:  Marisa Ferreira-Marques; Célia A Aveleira; Sara Carmo-Silva; Mariana Botelho; Luís Pereira de Almeida; Cláudia Cavadas
Journal:  Aging (Albany NY)       Date:  2016-07       Impact factor: 5.682

10.  A multi-tissue full lifespan epigenetic clock for mice.

Authors:  Michael J Thompson; Steve Horvath; Karolina Chwiałkowska; Liudmilla Rubbi; Aldons J Lusis; Richard C Davis; Anuj Srivastava; Ron Korstanje; Gary A Churchill; Matteo Pellegrini
Journal:  Aging (Albany NY)       Date:  2018-10-21       Impact factor: 5.682
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