Debasish Bandyopadhyay1, Lauren C Smith2, Daniel R Garcia3, Ram N Yadav4, Bimal K Banik5. 1. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. bandyopad@utpa.edu. 2. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. lcsmith@broncs.utpa.edu. 3. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. drgarcia4@broncs.utpa.edu. 4. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. yadavrn@utpa.edu. 5. Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA. banik@utpa.edu.
Abstract
BACKGROUND: Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research. FINDINGS: An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and aldehyde under sonication. Following this green approach a series of 2-aryl-4-phenyl-1H-imidazoles has been synthesized using diversely substituted aldehydes. CONCLUSIONS: A rapid and simple synthetic procedure to synthesize diversely substituted 2-aryl-4-phenyl-1H-imidazoles has been reported. Other salient features of this protocol include milder conditions, atom-economy, easy extraction, and minimum wastes. The present procedure may find application in the synthesis of biologically active molecules. Graphical Abstract An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and diversely substituted aldehydes under sonication.
BACKGROUND:Azaheterocycles are an important class of compounds because of their highly potent medicinal activities, and the imidazole subcategory is of special interest in regard to drug discovery research. FINDINGS: An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and aldehyde under sonication. Following this green approach a series of 2-aryl-4-phenyl-1H-imidazoles has been synthesized using diversely substituted aldehydes. CONCLUSIONS: A rapid and simple synthetic procedure to synthesize diversely substituted 2-aryl-4-phenyl-1H-imidazoles has been reported. Other salient features of this protocol include milder conditions, atom-economy, easy extraction, and minimum wastes. The present procedure may find application in the synthesis of biologically active molecules. Graphical Abstract An expeditious synthetic protocol of 2-aryl-4-phenyl-1H-imidazoles has been accomplished by reacting phenylglyoxal monohydrate, ammonium acetate, and diversely substituted aldehydes under sonication.
Entities:
Keywords:
Azaheterocycles; Green chemistry; Heterocycles; Imidazole; Medicinal chemistry; Ultrasound
Authors: Debasish Bandyopadhyay; Sanghamitra Mukherjee; Jose C Granados; John D Short; Bimal K Banik Journal: Eur J Med Chem Date: 2012-02-03 Impact factor: 6.514
Authors: Debasish Bandyopadhyay; Jessica Cruz; Liza D Morales; Hadi D Arman; Erica Cuate; Young S Lee; Bimal K Banik; Dae J Kim Journal: Future Med Chem Date: 2013-08 Impact factor: 3.808