Literature DB >> 26548489

Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix.

Geoffrey C Gurtner1, Victor W Wong2.   

Abstract

Fibroblasts have a central role in wound healing via matrix production, remodeling, and contraction. Their role as mechanoresponsive cells during tissue repair is evident, but the molecular mechanisms of this process remain uncertain. Filamin A, an intracellular protein that stabilizes the actin cytoskeleton regulates fibroblast-matrix interactions. Fibroblast defects in cytoskeletal dynamics may underlie key aspects of chronic wound pathophysiology.

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Year:  2015        PMID： 26548489     DOI： 10.1038/jid.2015.327

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  10 in total

Review 1.  Filamins in mechanosensing and signaling.

Authors:  Ziba Razinia; Toni Mäkelä; Jari Ylänne; David A Calderwood
Journal:  Annu Rev Biophys       Date:  2012-02-23       Impact factor: 12.981

Review 2.  Pushing back: wound mechanotransduction in repair and regeneration.

Authors:  Victor W Wong; Satoshi Akaishi; Michael T Longaker; Geoffrey C Gurtner
Journal:  J Invest Dermatol       Date:  2011-07-21       Impact factor: 8.551

Review 3.  Effect of negative pressure wound therapy on wound healing.

Authors:  Chenyu Huang; Tripp Leavitt; Lauren R Bayer; Dennis P Orgill
Journal:  Curr Probl Surg       Date:  2014-04-26       Impact factor: 1.909

4.  Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies.

Authors:  Geoffrey C Gurtner; Reinhold H Dauskardt; Victor W Wong; Kirit A Bhatt; Kenneth Wu; Ivan N Vial; Karine Padois; Joshua M Korman; Michael T Longaker
Journal:  Ann Surg       Date:  2011-08       Impact factor: 12.969

5.  Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix.

Authors:  Hamid Mohammadi; Vanessa I Pinto; Yongqiang Wang; Boris Hinz; Paul A Janmey; Christopher A McCulloch
Journal:  J Invest Dermatol       Date:  2015-07-02       Impact factor: 8.551

6.  Loss of keratinocyte focal adhesion kinase stimulates dermal proteolysis through upregulation of MMP9 in wound healing.

Authors:  Victor W Wong; Ravi K Garg; Michael Sorkin; Kristine C Rustad; Satoshi Akaishi; Kemal Levi; Emily R Nelson; Misha Tran; Robert Rennert; Wei Liu; Michael T Longaker; Reinhold H Dauskardt; Geoffrey C Gurtner
Journal:  Ann Surg       Date:  2014-12       Impact factor: 12.969

7.  Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.

Authors:  Victor W Wong; Kristine C Rustad; Satoshi Akaishi; Michael Sorkin; Jason P Glotzbach; Michael Januszyk; Emily R Nelson; Kemal Levi; Josemaria Paterno; Ivan N Vial; Anna A Kuang; Michael T Longaker; Geoffrey C Gurtner
Journal:  Nat Med       Date:  2011-12-11       Impact factor: 53.440

8.  Filamin A protects cells against force-induced apoptosis by stabilizing talin- and vinculin-containing cell adhesions.

Authors:  Vanessa I Pinto; Vincent W Senini; Yongqiang Wang; Mwayi P Kazembe; Christopher A McCulloch
Journal:  FASEB J       Date:  2013-10-04       Impact factor: 5.191

9.  Filamin A is required for vimentin-mediated cell adhesion and spreading.

Authors:  Hugh Kim; Fumihiko Nakamura; Wilson Lee; Yulia Shifrin; Pamela Arora; Christopher A McCulloch
Journal:  Am J Physiol Cell Physiol       Date:  2009-09-23       Impact factor: 4.249

10.  Human skin wounds: a major and snowballing threat to public health and the economy.

Authors:  Chandan K Sen; Gayle M Gordillo; Sashwati Roy; Robert Kirsner; Lynn Lambert; Thomas K Hunt; Finn Gottrup; Geoffrey C Gurtner; Michael T Longaker
Journal:  Wound Repair Regen       Date:  2009 Nov-Dec       Impact factor: 3.617
  10 in total
  1 in total

Review 1.  Gut homeostasis, injury, and healing: New therapeutic targets.

Authors:  Sema Oncel; Marc D Basson
Journal:  World J Gastroenterol       Date:  2022-05-07       Impact factor: 5.374
  1 in total

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