| Literature DB >> 26547693 |
Seoung Rak Lee1, Kiwon Jung2, Hyung Jun Noh3, Yong Joo Park1, Hye Lim Lee4, Kang Ro Lee1, Ki Sung Kang5, Ki Hyun Kim6.
Abstract
A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.Entities:
Keywords: Angiogenesis; Cerebroside; Hericiaceae; Hericium erinaceus; Nephrotoxicity
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Year: 2015 PMID： 26547693 DOI： 10.1016/j.bmcl.2015.10.092
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823