| Literature DB >> 26547586 |
Shiying Zhang1, Jianye Li1, Gaobiao Zhou1, Dawei Mu1, Jingmin Yan1, Jizhang Xing1, Zhiyong Yao1, Haibo Sheng1, Di Li1, Chao Lv1, Bin Sun1, Quan Hong1, Heqing Guo2.
Abstract
There is increasing evidence suggesting that establishment of sister chromatid cohesion N-acetyltransferase 1 (ESCO1) was involved in tumorigenesis. However, its role in bladder cancer remains unclear. In this study, we aimed to study the clinical correlation and biological significance of ESCO1 in bladder cancer. Our results showed that ESCO1 was significantly over-expressed in bladder cancer tissues compared with that in adjacent normal tissues. And, increased ESCO1 expression was significantly associated with higher grade (P < 0.001), higher tumor stage (P = 0.014), and multifocality (P = 0.042). Kaplan-Meier analysis and Cox proportional hazards model were performed to determine the prognostic significance of ESCO1, and the results showed that ESCO1 is a useful prognostic marker for bladder cancer patients. Moreover, we found that ESCO1 knockdown inhibited the growth, migration, and invasion of bladder cancer cells. In conclusion, our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer.Entities:
Keywords: Bladder cancer; Carcinogenesis; Chromosome instability gene; ESCO1; Prognostic factor
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Year: 2015 PMID： 26547586 DOI： 10.1007/s13277-015-4375-1
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283