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Literature DB >> 26547416

Speciation of precious metal anti-cancer complexes by NMR spectroscopy.

Abstract

Understanding the mechanism of action of anti-cancer agents is of paramount importance for drug development. NMR spectroscopy can provide insights into the kinetics and thermodynamics of the binding of metallodrugs to biomolecules. NMR is most sensitive for highly abundant I=1/2 nuclei with large magnetic moments. Polarization transfer can enhance NMR signals of insensitive nuclei at physiologically-relevant concentrations. This paper reviews NMR methods for speciation of precious metal anti-cancer complexes, including platinum-group and gold-based anti-cancer agents. Examples of NMR studies involving interactions with DNA and proteins in particular are highlighted.

Entities: Chemical Disease

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Year: 2015 PMID： 26547416 DOI： 10.1016/j.ddtec.2015.08.002

Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749

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Cited

4 in total

1. New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status.

Authors: Muhammad Altaf; Muhammad Monim-Ul-Mehboob; Abdel-Nasser Kawde; Giuseppe Corona; Roberto Larcher; Marcia Ogasawara; Naike Casagrande; Marta Celegato; Cinzia Borghese; Zahid H Siddik; Donatella Aldinucci; Anvarhusein A Isab
Journal: Oncotarget Date: 2017-01-03

Speciation of precious metal anti-cancer complexes by NMR spectroscopy.

1. New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status.

2. Tracking Reactions of Asymmetric Organo-Osmium Transfer Hydrogenation Catalysts in Cancer Cells.

3. In Vitro Activity of Monofunctional Pt-II Complex Based on 8-Aminoquinoline against Human Glioblastoma.

4. NMR studies of group 8 metallodrugs: ¹⁸⁷Os-enriched organo-osmium half-sandwich anticancer complex.

Speciation of precious metal anti-cancer complexes by NMR spectroscopy.

1. New bipyridine gold(III) dithiocarbamate-containing complexes exerted a potent anticancer activity against cisplatin-resistant cancer cells independent of p53 status.

2. Tracking Reactions of Asymmetric Organo-Osmium Transfer Hydrogenation Catalysts in Cancer Cells.

3. In Vitro Activity of Monofunctional Pt-II Complex Based on 8-Aminoquinoline against Human Glioblastoma.

4. NMR studies of group 8 metallodrugs: 187Os-enriched organo-osmium half-sandwich anticancer complex.

4. NMR studies of group 8 metallodrugs: ¹⁸⁷Os-enriched organo-osmium half-sandwich anticancer complex.