Meenakshi Dauwan1, Marieke J H Begemann2, Sophie M Heringa2, Iris E Sommer2. 1. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Clinical Neurophysiology and MEG Center, Neuroscience Campus, VU University Medical Center, Amsterdam, The Netherlands m.dauwan-3@umcutrecht.nl. 2. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands;
Abstract
BACKGROUND: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. METHODS: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. RESULTS: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g = .39, P < .001), positive (k = 15, n = 715: Hedges' g = .32, P < .01), negative (k = 18, n = 854: Hedges' g = .49, P < .001), and general (k = 10, n = 475: Hedges' g = .27, P < .05) symptoms, quality of life (k = 11, n = 770: Hedges' g = .55, P < .001), global functioning (k = 5, n = 342: Hedges' g = .32, P < .01), and depressive symptoms (k = 7, n = 337: Hedges' g = .71, P < .001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g = .32, P < .05), while exercise in general or in any other form had no effect on cognition. CONCLUSION: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.
BACKGROUND: Physical exercise may be valuable for patients with schizophrenia spectrum disorders as it may have beneficial effect on clinical symptoms, quality of life and cognition. METHODS: A systematic search was performed using PubMed (Medline), Embase, PsychInfo, and Cochrane Database of Systematic Reviews. Controlled and uncontrolled studies investigating the effect of any type of physical exercise interventions in schizophrenia spectrum disorders were included. Outcome measures were clinical symptoms, quality of life, global functioning, depression or cognition. Meta-analyses were performed using Comprehensive Meta-Analysis software. A random effects model was used to compute overall weighted effect sizes in Hedges' g. RESULTS: Twenty-nine studies were included, examining 1109 patients. Exercise was superior to control conditions in improving total symptom severity (k = 14, n = 719: Hedges' g = .39, P < .001), positive (k = 15, n = 715: Hedges' g = .32, P < .01), negative (k = 18, n = 854: Hedges' g = .49, P < .001), and general (k = 10, n = 475: Hedges' g = .27, P < .05) symptoms, quality of life (k = 11, n = 770: Hedges' g = .55, P < .001), global functioning (k = 5, n = 342: Hedges' g = .32, P < .01), and depressive symptoms (k = 7, n = 337: Hedges' g = .71, P < .001). Yoga, specifically, improved the cognitive subdomain long-term memory (k = 2, n = 184: Hedges' g = .32, P < .05), while exercise in general or in any other form had no effect on cognition. CONCLUSION: Physical exercise is a robust add-on treatment for improving clinical symptoms, quality of life, global functioning, and depressive symptoms in patients with schizophrenia. The effect on cognition is not demonstrated, but may be present for yoga.
Authors: Davy Vancampfort; Michel Probst; Thomas Scheewe; Katrien Maurissen; Kim Sweers; Jan Knapen; Marc De Hert Journal: Schizophr Res Date: 2011-04-14 Impact factor: 4.939
Authors: David Kimhy; Julia Vakhrusheva; Matthew N Bartels; Hilary F Armstrong; Jacob S Ballon; Samira Khan; Rachel W Chang; Marie C Hansen; Lindsey Ayanruoh; Amanda Lister; Eero Castrén; Edward E Smith; Richard P Sloan Journal: Schizophr Bull Date: 2015-03-23 Impact factor: 9.306
Authors: Frank-Gerald Pajonk; Thomas Wobrock; Oliver Gruber; Harald Scherk; Dorothea Berner; Inge Kaizl; Astrid Kierer; Stephanie Müller; Martin Oest; Tim Meyer; Martin Backens; Thomas Schneider-Axmann; Allen E Thornton; William G Honer; Peter Falkai Journal: Arch Gen Psychiatry Date: 2010-02
Authors: Ross Andel; Michael Crowe; Nancy L Pedersen; Laura Fratiglioni; Boo Johansson; Margaret Gatz Journal: J Gerontol A Biol Sci Med Sci Date: 2008-01 Impact factor: 6.053
Authors: H Takahashi; T Sassa; T Shibuya; M Kato; M Koeda; T Murai; M Matsuura; K Asai; T Suhara; Y Okubo Journal: Transl Psychiatry Date: 2012-03-20 Impact factor: 6.222
Authors: Davy Vancampfort; Michel Probst; Simon Rosenbaum; Philip B Ward; Tine Van Damme; James Mugisha Journal: Community Ment Health J Date: 2018-12-05
Authors: Garcia Ashdown-Franks; Joseph Firth; Rebekah Carney; Andre F Carvalho; Mats Hallgren; Ai Koyanagi; Simon Rosenbaum; Felipe B Schuch; Lee Smith; Marco Solmi; Davy Vancampfort; Brendon Stubbs Journal: Sports Med Date: 2020-01 Impact factor: 11.136
Authors: Joseph S DeLuca; Nicole D Andorko; Doha Chibani; Samantha Y Jay; Pamela J Rakhshan Rouhakhtar; Emily Petti; Mallory J Klaunig; Elizabeth C Thompson; Zachary B Millman; Kathleen M Connors; LeeAnn Akouri-Shan; John Fitzgerald; Samantha L Redman; Caroline Roemer; Miranda A Bridgwater; Jordan E DeVylder; Cheryl A King; Steven C Pitts; Shauna P Reinblatt; Heidi J Wehring; Kristin L Bussell; Natalee Solomon; Sarah M Edwards; Gloria M Reeves; Robert W Buchanan; Jason Schiffman Journal: J Psychother Integr Date: 2020-06