Geir Tryggvason1, Fridbert Jonasson2,3, Mary Frances Cotch4, Chuan-Ming Li5, Howard J Hoffman5, Christa L Themann6, Gudny Eiriksdottir7, Jóhanna Eyrún Sverrisdottir7, Tamara B Harris8, Lenore J Launer8, Vilmundur Gudnason3,7, Hannes Petersen3,9. 1. Department of Otolaryngology-Head and Neck Surgery, Oslo University Hospital, Oslo, Norway. 2. Department of Ophthalmology, Landspitali University Hospital, Reykjavik, Iceland. 3. Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 4. Division of Epidemiology and Clinical Applications, National Eye Institute (NEI), National Institutes of Health (NIH), Bethesda, MD, USA. 5. Epidemiology and Statistics Program, National Institute on Deafness and Other Communication Disorders (NIDCD), National Institutes of Health (NIH), Bethesda, MD, USA. 6. Hearing Loss Prevention Team, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, OH, USA. 7. Icelandic Heart Association, Kopavogur, Iceland. 8. Laboratory of Population Sciences, National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA. 9. Department of Otolaryngology-Head and Neck Surgery, Landspitali University Hospital, Reykjavik, Iceland.
Abstract
PURPOSE: To determine whether adults, aged 66-96 years, with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), or primary open-angle glaucoma (POAG) have poorer hearing than controls of similar age. METHODS: Case (XFS/XFG and POAG) and control status was diagnosed in the Reykjavik Glaucoma Studies (RGS) using slit-lamp examination, visual field testing and optic disc photographs; the RGS data were merged with the Age, Gene/Environment Susceptibility-Reykjavik Study that collected hearing data using air-conduction, pure-tone thresholds obtained at 0.5, 1, 2, 3, 4, 6 and 8 kHz categorized by better ear and worse ear, based on pure-tone averages (PTAs) calculated separately for low and middle frequencies (PTA512 - mean of thresholds at 0.5, 1 and 2 kHz) and high frequencies (PTA3468 - mean of thresholds at 3, 4, 6 and 8 kHz). Multivariable linear regression was used to test for differences in PTAs between cases and controls. RESULTS: The mean age for 158 XFS/XFG cases (30.4% male) was 77.4 years, 95 POAG cases (35.8% male) was 77.9 years, and 123 controls (46.3% male) was 76.8 years. Using multivariable linear regression analysis, there were no consistent, statistically significant differences in PTAs between the two case groups and controls in either the low- or high-frequency range, even when stratified by age group. CONCLUSION: Among the older individuals examined in this study hearing loss is highly prevalent and strongly associated with male gender and increasing age. As we did not find consistent statistically significant difference in hearing between cases and controls the diagnosis of XFS/XFG or POAG does not as such routinely call for audiological evaluation.
PURPOSE: To determine whether adults, aged 66-96 years, with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), or primary open-angle glaucoma (POAG) have poorer hearing than controls of similar age. METHODS: Case (XFS/XFG and POAG) and control status was diagnosed in the Reykjavik Glaucoma Studies (RGS) using slit-lamp examination, visual field testing and optic disc photographs; the RGS data were merged with the Age, Gene/Environment Susceptibility-Reykjavik Study that collected hearing data using air-conduction, pure-tone thresholds obtained at 0.5, 1, 2, 3, 4, 6 and 8 kHz categorized by better ear and worse ear, based on pure-tone averages (PTAs) calculated separately for low and middle frequencies (PTA512 - mean of thresholds at 0.5, 1 and 2 kHz) and high frequencies (PTA3468 - mean of thresholds at 3, 4, 6 and 8 kHz). Multivariable linear regression was used to test for differences in PTAs between cases and controls. RESULTS: The mean age for 158 XFS/XFG cases (30.4% male) was 77.4 years, 95 POAG cases (35.8% male) was 77.9 years, and 123 controls (46.3% male) was 76.8 years. Using multivariable linear regression analysis, there were no consistent, statistically significant differences in PTAs between the two case groups and controls in either the low- or high-frequency range, even when stratified by age group. CONCLUSION: Among the older individuals examined in this study hearing loss is highly prevalent and strongly associated with male gender and increasing age. As we did not find consistent statistically significant difference in hearing between cases and controls the diagnosis of XFS/XFG or POAG does not as such routinely call for audiological evaluation.
Authors: Bao Jian Fan; Louis R Pasquale; Douglas Rhee; Tiansen Li; Jonathan L Haines; Janey L Wiggs Journal: Invest Ophthalmol Vis Sci Date: 2011-04-12 Impact factor: 4.799
Authors: Ursula Schlötzer-Schrehardt; Francesca Pasutto; Pascal Sommer; Ian Hornstra; Friedrich E Kruse; Gottfried O H Naumann; André Reis; Matthias Zenkel Journal: Am J Pathol Date: 2008-10-30 Impact factor: 4.307
Authors: Hugues Aschard; Jae H Kang; Adriana I Iglesias; Pirro Hysi; Jessica N Cooke Bailey; Anthony P Khawaja; R Rand Allingham; Allison Ashley-Koch; Richard K Lee; Sayoko E Moroi; Murray H Brilliant; Gadi Wollstein; Joel S Schuman; John H Fingert; Donald L Budenz; Tony Realini; Terry Gaasterland; William K Scott; Kuldev Singh; Arthur J Sit; Robert P Igo; Yeunjoo E Song; Lisa Hark; Robert Ritch; Douglas J Rhee; Vikas Gulati; Shane Haven; Douglas Vollrath; Donald J Zack; Felipe Medeiros; Robert N Weinreb; Ching-Yu Cheng; Daniel I Chasman; William G Christen; Margaret A Pericak-Vance; Yutao Liu; Peter Kraft; Julia E Richards; Bernard A Rosner; Michael A Hauser; Caroline C W Klaver; Cornelia M vanDuijn; Jonathan Haines; Janey L Wiggs; Louis R Pasquale Journal: Eur J Hum Genet Date: 2017-08-30 Impact factor: 5.351