Literature DB >> 26546858

Bridging the translational gap: collaborative drug development and dispelling the stigma of commercialization.

Helen W H Yu1.   

Abstract

The current drug discovery and development process is stalling the translation of basic science into lifesaving products. Known as the 'Valley of Death', the traditional technology transfer model fails to bridge the gap between early-stage discoveries and preclinical research to advance innovations beyond the discovery phase. In addition, the stigma associated with 'commercialization' detracts from the importance of efficient translation of basic research. Here, I introduce a drug discovery model whereby the respective expertise of academia and industry are brought together to take promising discoveries through to proof of concept as a way to derisk the drug discovery and development process. Known as the 'integrated drug discovery model', I examine here the extent to which existing legal frameworks support this model.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Mesh:

Year:  2015        PMID: 26546858     DOI: 10.1016/j.drudis.2015.10.013

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  5 in total

1.  PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool.

Authors:  Yen-Wei Chen; Graciel Diamante; Jessica Ding; Thien Xuan Nghiem; Jessica Yang; Sung-Min Ha; Peter Cohn; Douglas Arneson; Montgomery Blencowe; Jennifer Garcia; Nima Zaghari; Paul Patel; Xia Yang
Journal:  iScience       Date:  2022-03-10

2.  Return of Benefit to Society of Publicly Funded Innovations to Combat COVID-19.

Authors:  Helen Yu
Journal:  Inquiry       Date:  2021 Jan-Dec       Impact factor: 1.730

3.  New York University School of Medicine Drug Development Educational Program: 2-Year Benchmark.

Authors:  J Plaksin; R M Cymerman; R Caso Caso; C Galeano; R Ramasamy; G Gold-von Simson
Journal:  Clin Transl Sci       Date:  2016-10-01       Impact factor: 4.689

Review 4.  Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.

Authors:  Jenna E Koschnitzky; Richard F Keep; David D Limbrick; James P McAllister; Jill A Morris; Jennifer Strahle; Yun C Yung
Journal:  Fluids Barriers CNS       Date:  2018-03-27

Review 5.  Improving target assessment in biomedical research: the GOT-IT recommendations.

Authors:  Christoph H Emmerich; Lorena Martinez Gamboa; Martine C J Hofmann; Marc Bonin-Andresen; Olga Arbach; Pascal Schendel; Björn Gerlach; Katja Hempel; Anton Bespalov; Ulrich Dirnagl; Michael J Parnham
Journal:  Nat Rev Drug Discov       Date:  2020-11-16       Impact factor: 112.288

  5 in total

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