Jiufeng Sun1, De Wu1, Huiqiong Zhou1, Huan Zhang1, Dawei Guan1, Xiang He1, Songwu Cai1, Changwen Ke2, Jinyan Lin1. 1. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China. 2. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong, PR China. Electronic address: kecw1965@aliyun.com.
Abstract
OBJECTIVES: The third largest historical outbreak of dengue occurred during July to December 2014, in 20 of 21 cities of Guangdong, China. The epidemiological and molecular characteristics of the introduction, expansion and phylogeny of the DENV isolates involved in this outbreak were investigated. METHODS: A combination analyses of epidemiological characteristics and genetic diversity of dengue virus was performed in this study. RESULTS: In total, 45,236 cases and 6 fatalities were reported. Unemployed individuals, retirees and retailers were the most affected populations. A total of 6024 cases were verified to have DENV infections by nucleic acid detection, of which 5947, 74 and 3 were confirmed to have DENV-1, -2, and -3 infections, respectively. Phylogenetic analyses of DENV-1 isolates were assigned into three genotypes (I, IV, and V). Genotype V was the predominant genotype that likely originated from Singapore. The DENV-2 isolates were assigned to the Cosmopolitan and Asian I genotypes. A unique DENV-3 isolate (genotype III) shared high similarity with isolates obtained from Guangdong in 2013. CONCLUSIONS: A combination analyses demonstrated the multiple geographical origins of this outbreak, and highlight the importance of early detection, the case management and vector surveillance for preventing further dengue epidemics in Guangdong.
OBJECTIVES: The third largest historical outbreak of dengue occurred during July to December 2014, in 20 of 21 cities of Guangdong, China. The epidemiological and molecular characteristics of the introduction, expansion and phylogeny of the DENV isolates involved in this outbreak were investigated. METHODS: A combination analyses of epidemiological characteristics and genetic diversity of dengue virus was performed in this study. RESULTS: In total, 45,236 cases and 6 fatalities were reported. Unemployed individuals, retirees and retailers were the most affected populations. A total of 6024 cases were verified to have DENV infections by nucleic acid detection, of which 5947, 74 and 3 were confirmed to have DENV-1, -2, and -3 infections, respectively. Phylogenetic analyses of DENV-1 isolates were assigned into three genotypes (I, IV, and V). Genotype V was the predominant genotype that likely originated from Singapore. The DENV-2 isolates were assigned to the Cosmopolitan and Asian I genotypes. A unique DENV-3 isolate (genotype III) shared high similarity with isolates obtained from Guangdong in 2013. CONCLUSIONS: A combination analyses demonstrated the multiple geographical origins of this outbreak, and highlight the importance of early detection, the case management and vector surveillance for preventing further dengue epidemics in Guangdong.
Authors: Lingcai Kong; Jinfeng Wang; Zhongjie Li; Shengjie Lai; Qiyong Liu; Haixia Wu; Weizhong Yang Journal: Int J Environ Res Public Health Date: 2018-05-31 Impact factor: 3.390
Authors: L Huang; X Luo; J Shao; H Yan; Y Qiu; P Ke; W Zheng; B Xu; W Li; D Sun; D Cao; C Chen; F Zhuo; X Lin; F Tang; B Bao; Y Zhou; X Zhang; H Li; J Li; D Wan; L Yang; Y Chen; Q Zhong; X Gu; J Liu; L Huang; R Xie; X Li; Y Xu; Z Luo; M Liao; H Wang; L Sun; H Li; G W Lau; C Duan Journal: Eur J Clin Microbiol Infect Dis Date: 2015-12-23 Impact factor: 5.103