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Literature DB >> 26546730

Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes.

Abstract

Human pluripotent stem cells (hPSCs)-derived cardiomyocytes (hPSC-CMs) represent a potential indefinite cell supply for cardiac tissue engineering and possibly regenerative medicine applications. However, these cells are immature compared with adult ventricular cardiomyocytes. In order to overcome this limitation, an engineered platform, called biowire, was devised to provide cultured cardiomyocytes important biomimetic cues present during embryo development, such as three-dimensional cell culture, extracellular matrix composition, soluble factors and pacing through electrical stimulation, to induce the maturation of hPSC-CMs in vitro.

Entities: Species

Keywords: Biomimetic cues; Cardiomyocyte; Maturation; Stem cells; Tissue engineering

Mesh：

Year: 2015 PMID： 26546730 DOI： 10.1016/j.ymeth.2015.11.005

Source DB: PubMed Journal: Methods ISSN： 1046-2023 Impact factor: 3.608

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Cited

17 in total

Review 1. Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.

Authors: Kacey Ronaldson-Bouchard; Gordana Vunjak-Novakovic
Journal: Cell Stem Cell Date: 2018-03-01 Impact factor: 24.633

Review 2. Towards chamber specific heart-on-a-chip for drug testing applications.

Authors: Yimu Zhao; Naimeh Rafatian; Erika Yan Wang; Qinghua Wu; Benjamin F L Lai; Rick Xingze Lu; Houman Savoji; Milica Radisic
Journal: Adv Drug Deliv Rev Date: 2020-01-07 Impact factor: 15.470

Review 3. The Role of Reactive Oxygen Species in In Vitro Cardiac Maturation.

Authors: Nima Momtahan; Cody O Crosby; Janet Zoldan
Journal: Trends Mol Med Date: 2019-05-09 Impact factor: 11.951

Review 4. Cardiovascular disease models: A game changing paradigm in drug discovery and screening.

Authors: Houman Savoji; Mohammad Hossein Mohammadi; Naimeh Rafatian; Masood Khaksar Toroghi; Erika Yan Wang; Yimu Zhao; Anastasia Korolj; Samad Ahadian; Milica Radisic
Journal: Biomaterials Date: 2018-10-01 Impact factor: 12.479

Review 5. (De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.

Authors: Ava M Obenaus; Molly Y Mollica; Nathan J Sniadecki
Journal: Adv Healthc Mater Date: 2020-01-17 Impact factor: 9.933

Review 6. Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation.

Authors: Olivia T Ly; Grace E Brown; Yong Duk Han; Dawood Darbar; Salman R Khetani
Journal: Exp Biol Med (Maywood) Date: 2021-04-25

Biowire platform for maturation of human pluripotent stem cell-derived cardiomyocytes.

Review 1. Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development.

Review 2. Towards chamber specific heart-on-a-chip for drug testing applications.

Review 3. The Role of Reactive Oxygen Species in In Vitro Cardiac Maturation.

Review 4. Cardiovascular disease models: A game changing paradigm in drug discovery and screening.

Review 5. (De)form and Function: Measuring Cellular Forces with Deformable Materials and Deformable Structures.

Review 6. Bioengineering approaches to mature induced pluripotent stem cell-derived atrial cardiomyocytes to model atrial fibrillation.

Review 7. Bioengineering Approaches to Mature Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Review 8. Microfabricated Physiological Models for In Vitro Drug Screening Applications.

9. Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells.

10. Contractile Skeletal Muscle Cells Cultured with a Conducting Soft Wire for Effective, Selective Stimulation.