Literature DB >> 26546166

Genetics meets epigenetics: Genetic variants that modulate noncoding RNA in cardiovascular diseases.

Martina Calore1, Leon J De Windt1, Alessandra Rampazzo2.   

Abstract

After the recent description of the human genome by the ENCODE and the FANTOM consortia, major attention has been addressed to the so-called "genomic noise", which mainly consists of noncoding RNAs (ncRNAs). Among them, microRNAs and long non-coding RNAs have been demonstrated to modulate gene expression and to be involved in several human diseases. Since ncRNAs and their targets are encoded in the genome, genetic principles apply. Common variants are supposed to influence the expression level and the functionality of ncRNAs, with subsequent differential regulation of their target genes. Moreover, several reports showed that polymorphisms in ncRNA or their target genes play a role in the development of cardiovascular adverse phenotype. Here, we provide an overview of the effects of these variations in cardiovascular diseases.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Cardiovascular diseases; Common genetic variants; Long noncoding RNAs; MiRNAs

Mesh：

Substances：

Year:  2015        PMID： 26546166     DOI： 10.1016/j.yjmcc.2015.10.028

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


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