Young-Eun Cho1, Hyung-Suk Kim2, Chen Lai3, Ansley Stanfill4, Ann Cashion5. 1. National Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: young-eun.cho@nih.gov. 2. National Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: kimhy@mail.nih.gov. 3. National Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: laichi@mail.nih.gov. 4. University of Pittsburgh, 440 Victoria Building, 3500 Victoria St, Pittsburgh, PA 15261, USA. Electronic address: stanfill@pitt.edu. 5. National Institute of Nursing Research, National Institutes of Health, 3 Center Drive, Building 3, Room 5E26, Bethesda, MD 20892-2178, USA. Electronic address: ann.cashion@nih.gov.
Abstract
OBJECTIVE: Weight gain after kidney transplantation (Tx) is considered a risk factor for poor outcomes. Increased oxidative stress is associated with not only chronic renal disease and Tx, but also obesity and cardiovascular disease. The aim of this pilot study was to test whether oxidative stress is related to weight gain at 12-months after kidney Tx and to obtain preliminary insight into potential mechanisms involved. DESIGN & METHODS: Recipients (n=33) were classified into two groups; weight loss and weight gain, based on their weight changes at 12-months post-transplant. Total antioxidant capacity (TAOC) and lipid peroxidation (TBARS) were measured to evaluate oxidative stress from plasma at baseline and 12-months. A secondary data analysis was conducted to identify potential gene regulation. RESULTS: Seventeen recipients lost (-6.63±5.52kg), and sixteen recipients gained weight (8.94±6.18kg). TAOC was significantly decreased at 12-months compared to baseline for the total group, however, there was no significant difference between groups at either time point. TBARS was higher in weight gain group, at both time points, and it was significantly higher at 12-months (p=0.012). Gene expression profiling analysis showed that 7 transcripts annotated to reactive oxygen species related genes in adipose tissue were expressed significantly lower in weight gain group at baseline, which might be a negative feedback mechanism to reduce oxidative stress. CONCLUSION: These results may indicate that elevated oxidative stress (TBARS) is associated with weight gain after kidney Tx and that incorporating early clinical prevention strategies known to decrease oxidative stress could be recommended. Published by Elsevier Inc.
OBJECTIVE:Weight gain after kidney transplantation (Tx) is considered a risk factor for poor outcomes. Increased oxidative stress is associated with not only chronic renal disease and Tx, but also obesity and cardiovascular disease. The aim of this pilot study was to test whether oxidative stress is related to weight gain at 12-months after kidney Tx and to obtain preliminary insight into potential mechanisms involved. DESIGN & METHODS: Recipients (n=33) were classified into two groups; weight loss and weight gain, based on their weight changes at 12-months post-transplant. Total antioxidant capacity (TAOC) and lipid peroxidation (TBARS) were measured to evaluate oxidative stress from plasma at baseline and 12-months. A secondary data analysis was conducted to identify potential gene regulation. RESULTS: Seventeen recipients lost (-6.63±5.52kg), and sixteen recipients gained weight (8.94±6.18kg). TAOC was significantly decreased at 12-months compared to baseline for the total group, however, there was no significant difference between groups at either time point. TBARS was higher in weight gain group, at both time points, and it was significantly higher at 12-months (p=0.012). Gene expression profiling analysis showed that 7 transcripts annotated to reactive oxygen species related genes in adipose tissue were expressed significantly lower in weight gain group at baseline, which might be a negative feedback mechanism to reduce oxidative stress. CONCLUSION: These results may indicate that elevated oxidative stress (TBARS) is associated with weight gain after kidney Tx and that incorporating early clinical prevention strategies known to decrease oxidative stress could be recommended. Published by Elsevier Inc.
Entities:
Keywords:
Kidney transplantation; Oxidative stress; Weight gain
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