Literature DB >> 26545809

[Keloid scars (part I): Clinical presentation, epidemiology, histology and pathogenesis].

C Philandrianos1, N Kerfant2, C Jaloux3, L Martinet4, B Bertrand3, D Casanova3.   

Abstract

Keloid scars are a dysregulated response to cutaneous wound healing and are characterized by excessive deposition of collagen. Clinical and histological aspects are typical but they are often confused with hypertrophic scars. Principal pathogenesis is abnormal regulation of the collagen equilibrium because of TGFβ. In this first part, clinical characteristics, physiopathology and histology of keloid scars are explained.
Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Chéloïde; Cicatrice; Collagen bundle; Collagène hyalin; Fibroblast; Fibroblaste; Fibrose; Fibrosis; Keloid; Scar; TGFβ

Mesh:

Substances:

Year:  2015        PMID: 26545809     DOI: 10.1016/j.anplas.2015.09.005

Source DB:  PubMed          Journal:  Ann Chir Plast Esthet        ISSN: 0294-1260            Impact factor:   0.660


  5 in total

1.  Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts.

Authors:  Xiuxia Wang; Yan Ma; Zhen Gao; Jun Yang
Journal:  Stem Cell Res Ther       Date:  2018-02-21       Impact factor: 6.832

2.  FoxO3a depletion accelerates cutaneous wound healing by regulating epithelial‑mesenchymal transition through β‑catenin activation.

Authors:  Ting Liu; Jing-Zhuo Huang; Ze-Yuan Lei; Rong-Shuai Yan; Dong-Li Fan
Journal:  Mol Med Rep       Date:  2020-01-03       Impact factor: 2.952

3.  Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine.

Authors:  Jinxiu Yang; Shiyi Li; Leren He; Minliang Chen
Journal:  Burns Trauma       Date:  2021-09-11

4.  Near-infrared-emitting nanoparticles activate collagen synthesis via TGFβ signaling.

Authors:  Myung Hyun Kang; Han Young Yu; Goon-Tae Kim; Ji Eun Lim; Seunghun Jang; Tae-Sik Park; Joung Kyu Park
Journal:  Sci Rep       Date:  2020-08-06       Impact factor: 4.379

5.  Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.

Authors:  Wenchang Lv; Min Wu; Yuping Ren; Xiao Luo; Weijie Hu; Qi Zhang; Yiping Wu
Journal:  Mol Med Rep       Date:  2020-11-17       Impact factor: 2.952

  5 in total

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