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Literature DB >> 26544932

Aire Gets Company for Immune Tolerance.

Abstract

A specialized subset of epithelial cells in the thymus "promiscuously" transcribes thousands of peripheral genes to ensure that developing T cells can test their antigen receptors for dangerous autoreactivity. New findings by Takaba et al. indicate that the transcription factor Fezf2 acts independently of Aire in thymic epithelial cells to generate "genetic noise" for immunological tolerance.

Entities: Gene

Mesh：

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Year: 2015 PMID： 26544932 DOI： 10.1016/j.cell.2015.10.057

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

7 in total

Review 1. Update on Aire and thymic negative selection.

Authors: Geraldo A Passos; Cesar A Speck-Hernandez; Amanda F Assis; Daniella A Mendes-da-Cruz
Journal: Immunology Date: 2017-09-26 Impact factor: 7.397

2. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

Authors: Ernna H Oliveira; Claudia Macedo; Cristhianna V Collares; Ana Carolina Freitas; Paula Barbim Donate; Elza T Sakamoto-Hojo; Eduardo A Donadi; Geraldo A Passos
Journal: Front Immunol Date: 2016-11-23 Impact factor: 7.561

3. The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

Authors: Stephane Becart; Karen B Whittington; Amanda Prislovsky; Navin L Rao; Edward F Rosloniec
Journal: PLoS One Date: 2021-01-19 Impact factor: 3.240

Aire Gets Company for Immune Tolerance.

Review 1. Update on Aire and thymic negative selection.

2. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

3. The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

4. Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes.

Review 5. Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4⁺FOXP3⁺ T Regulatory Cells.

6. Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells.

Review 7. Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development.

Aire Gets Company for Immune Tolerance.

Review 1. Update on Aire and thymic negative selection.

2. Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells.

3. The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses.

4. Aire Disruption Influences the Medullary Thymic Epithelial Cell Transcriptome and Interaction With Thymocytes.

Review 5. Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4+FOXP3+ T Regulatory Cells.

6. Aire Gene Influences the Length of the 3' UTR of mRNAs in Medullary Thymic Epithelial Cells.

Review 7. Thymic Epithelial Cells Contribute to Thymopoiesis and T Cell Development.

Review 5. Antigen-Specificity in the Thymic Development and Peripheral Activity of CD4⁺FOXP3⁺ T Regulatory Cells.